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First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome

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First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome. / Fruscalzo, Arrigo; Frommer, Julia; Londero, Ambrogio P; Henze, Andrea; Schweigert, Florian J; Nofer, Jerzy-Roch; Steinhard, Johannes; Klockenbusch, Walter; Schmitz, Ralf; Raila, Jens.

In: ARCH GYNECOL OBSTET, Vol. 295, No. 5, 05.2017, p. 1157-1165.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fruscalzo, A, Frommer, J, Londero, AP, Henze, A, Schweigert, FJ, Nofer, J-R, Steinhard, J, Klockenbusch, W, Schmitz, R & Raila, J 2017, 'First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome', ARCH GYNECOL OBSTET, vol. 295, no. 5, pp. 1157-1165. https://doi.org/10.1007/s00404-017-4338-4

APA

Fruscalzo, A., Frommer, J., Londero, A. P., Henze, A., Schweigert, F. J., Nofer, J-R., Steinhard, J., Klockenbusch, W., Schmitz, R., & Raila, J. (2017). First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome. ARCH GYNECOL OBSTET, 295(5), 1157-1165. https://doi.org/10.1007/s00404-017-4338-4

Vancouver

Fruscalzo A, Frommer J, Londero AP, Henze A, Schweigert FJ, Nofer J-R et al. First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome. ARCH GYNECOL OBSTET. 2017 May;295(5):1157-1165. https://doi.org/10.1007/s00404-017-4338-4

Bibtex

@article{32ae844e87a2484f9e54072c8d10230e,
title = "First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome",
abstract = "PURPOSE: To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).METHODS: Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).RESULTS: We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).CONCLUSIONS: First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.",
keywords = "Birth Weight, Case-Control Studies, Female, Gestational Age, Humans, Infant, Newborn, Infant, Small for Gestational Age/blood, Placenta Growth Factor/blood, Pre-Eclampsia/blood, Prealbumin/analysis, Pregnancy, Pregnancy Trimester, First/blood, Retinol-Binding Proteins, Plasma/analysis, Vascular Endothelial Growth Factor Receptor-1/blood, Vitamin A/blood",
author = "Arrigo Fruscalzo and Julia Frommer and Londero, {Ambrogio P} and Andrea Henze and Schweigert, {Florian J} and Jerzy-Roch Nofer and Johannes Steinhard and Walter Klockenbusch and Ralf Schmitz and Jens Raila",
year = "2017",
month = may,
doi = "10.1007/s00404-017-4338-4",
language = "English",
volume = "295",
pages = "1157--1165",
journal = "ARCH GYNECOL OBSTET",
issn = "0932-0067",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome

AU - Fruscalzo, Arrigo

AU - Frommer, Julia

AU - Londero, Ambrogio P

AU - Henze, Andrea

AU - Schweigert, Florian J

AU - Nofer, Jerzy-Roch

AU - Steinhard, Johannes

AU - Klockenbusch, Walter

AU - Schmitz, Ralf

AU - Raila, Jens

PY - 2017/5

Y1 - 2017/5

N2 - PURPOSE: To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).METHODS: Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).RESULTS: We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).CONCLUSIONS: First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.

AB - PURPOSE: To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).METHODS: Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).RESULTS: We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).CONCLUSIONS: First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.

KW - Birth Weight

KW - Case-Control Studies

KW - Female

KW - Gestational Age

KW - Humans

KW - Infant, Newborn

KW - Infant, Small for Gestational Age/blood

KW - Placenta Growth Factor/blood

KW - Pre-Eclampsia/blood

KW - Prealbumin/analysis

KW - Pregnancy

KW - Pregnancy Trimester, First/blood

KW - Retinol-Binding Proteins, Plasma/analysis

KW - Vascular Endothelial Growth Factor Receptor-1/blood

KW - Vitamin A/blood

U2 - 10.1007/s00404-017-4338-4

DO - 10.1007/s00404-017-4338-4

M3 - SCORING: Journal article

C2 - 28337595

VL - 295

SP - 1157

EP - 1165

JO - ARCH GYNECOL OBSTET

JF - ARCH GYNECOL OBSTET

SN - 0932-0067

IS - 5

ER -