First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome
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First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome. / Fruscalzo, Arrigo; Frommer, Julia; Londero, Ambrogio P; Henze, Andrea; Schweigert, Florian J; Nofer, Jerzy-Roch; Steinhard, Johannes; Klockenbusch, Walter; Schmitz, Ralf; Raila, Jens.
in: ARCH GYNECOL OBSTET, Jahrgang 295, Nr. 5, 05.2017, S. 1157-1165.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome
AU - Fruscalzo, Arrigo
AU - Frommer, Julia
AU - Londero, Ambrogio P
AU - Henze, Andrea
AU - Schweigert, Florian J
AU - Nofer, Jerzy-Roch
AU - Steinhard, Johannes
AU - Klockenbusch, Walter
AU - Schmitz, Ralf
AU - Raila, Jens
PY - 2017/5
Y1 - 2017/5
N2 - PURPOSE: To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).METHODS: Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).RESULTS: We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).CONCLUSIONS: First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.
AB - PURPOSE: To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA).METHODS: Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37).RESULTS: We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05).CONCLUSIONS: First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.
KW - Birth Weight
KW - Case-Control Studies
KW - Female
KW - Gestational Age
KW - Humans
KW - Infant, Newborn
KW - Infant, Small for Gestational Age/blood
KW - Placenta Growth Factor/blood
KW - Pre-Eclampsia/blood
KW - Prealbumin/analysis
KW - Pregnancy
KW - Pregnancy Trimester, First/blood
KW - Retinol-Binding Proteins, Plasma/analysis
KW - Vascular Endothelial Growth Factor Receptor-1/blood
KW - Vitamin A/blood
U2 - 10.1007/s00404-017-4338-4
DO - 10.1007/s00404-017-4338-4
M3 - SCORING: Journal article
C2 - 28337595
VL - 295
SP - 1157
EP - 1165
JO - ARCH GYNECOL OBSTET
JF - ARCH GYNECOL OBSTET
SN - 0932-0067
IS - 5
ER -