Research ExplorerPublicationsFinite element analyses of human vertebral bodies embedded i...

Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength

Standard

Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength. / Lu, Yongtao; Maquer, Ghislain; Museyko, Oleg; Püschel, Klaus; Engelke, Klaus; Zysset, Philippe; Morlock, Michael; Huber, Gerd.

In: J BIOMECH, Vol. 47, No. 10, 18.07.2014, p. 2512-2516.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lu, Y, Maquer, G, Museyko, O, Püschel, K, Engelke, K, Zysset, P, Morlock, M & Huber, G 2014, 'Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength', J BIOMECH, vol. 47, no. 10, pp. 2512-2516. https://doi.org/10.1016/j.jbiomech.2014.04.015

APA

Lu, Y., Maquer, G., Museyko, O., Püschel, K., Engelke, K., Zysset, P., Morlock, M., & Huber, G. (2014). Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength. J BIOMECH, 47(10), 2512-2516. https://doi.org/10.1016/j.jbiomech.2014.04.015

Vancouver

Lu Y, Maquer G, Museyko O, Püschel K, Engelke K, Zysset P et al. Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength. J BIOMECH. 2014 Jul 18;47(10):2512-2516. https://doi.org/10.1016/j.jbiomech.2014.04.015

Bibtex

@article{bdda91dd9a8b45fab9b68c40d2c89a29,
title = "Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength",
abstract = "Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body provide better prediction of vertebral strength than dual energy X-ray absorptiometry. However, most models were validated against compression of vertebral bodies with endplates embedded in polymethylmethalcrylate (PMMA). Yet, loading being as important as bone density, the absence of intervertebral disc (IVD) affects the strength. Accordingly, the aim was to assess the strength predictions of the classic FE models (vertebral body embedded) against the in vitro and in silico strengths of vertebral bodies loaded via IVDs. High resolution peripheral QCT (HR-pQCT) were performed on 13 segments (T11/T12/L1). T11 and L1 were augmented with PMMA and the samples were tested under a 4° wedge compression until failure of T12. Specimen-specific model was generated for each T12 from the HR-pQCT data. Two FE sets were created: FE-PMMA refers to the classical vertebral body embedded model under axial compression; FE-IVD to their loading via hyperelastic IVD model under the wedge compression as conducted experimentally. Results showed that FE-PMMA models overestimated the experimental strength and their strength prediction was satisfactory considering the different experimental set-up. On the other hand, the FE-IVD models did not prove significantly better (Exp/FE-PMMA: R²=0.68; Exp/FE-IVD: R²=0.71, p=0.84). In conclusion, FE-PMMA correlates well with in vitro strength of human vertebral bodies loaded via real IVDs and FE-IVD with hyperelastic IVDs do not significantly improve this correlation. Therefore, it seems not worth adding the IVDs to vertebral body models until fully validated patient-specific IVD models become available.",
keywords = "Absorptiometry, Photon, Adult, Aged, Algorithms, Biomechanical Phenomena, Bone Density, Compressive Strength, Elasticity, Female, Finite Element Analysis, Humans, Intervertebral Disc, Lumbar Vertebrae, Middle Aged, Models, Biological, Models, Statistical, Polymethyl Methacrylate, Spine, Stress, Mechanical, Thoracic Vertebrae, Tomography, X-Ray Computed",
author = "Yongtao Lu and Ghislain Maquer and Oleg Museyko and Klaus P{\"u}schel and Klaus Engelke and Philippe Zysset and Michael Morlock and Gerd Huber",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = jul,
day = "18",
doi = "10.1016/j.jbiomech.2014.04.015",
language = "English",
volume = "47",
pages = "2512--2516",
journal = "J BIOMECH",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "10",

}

RIS

TY - JOUR

T1 - Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength

AU - Lu, Yongtao

AU - Maquer, Ghislain

AU - Museyko, Oleg

AU - Püschel, Klaus

AU - Engelke, Klaus

AU - Zysset, Philippe

AU - Morlock, Michael

AU - Huber, Gerd

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/7/18

Y1 - 2014/7/18

N2 - Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body provide better prediction of vertebral strength than dual energy X-ray absorptiometry. However, most models were validated against compression of vertebral bodies with endplates embedded in polymethylmethalcrylate (PMMA). Yet, loading being as important as bone density, the absence of intervertebral disc (IVD) affects the strength. Accordingly, the aim was to assess the strength predictions of the classic FE models (vertebral body embedded) against the in vitro and in silico strengths of vertebral bodies loaded via IVDs. High resolution peripheral QCT (HR-pQCT) were performed on 13 segments (T11/T12/L1). T11 and L1 were augmented with PMMA and the samples were tested under a 4° wedge compression until failure of T12. Specimen-specific model was generated for each T12 from the HR-pQCT data. Two FE sets were created: FE-PMMA refers to the classical vertebral body embedded model under axial compression; FE-IVD to their loading via hyperelastic IVD model under the wedge compression as conducted experimentally. Results showed that FE-PMMA models overestimated the experimental strength and their strength prediction was satisfactory considering the different experimental set-up. On the other hand, the FE-IVD models did not prove significantly better (Exp/FE-PMMA: R²=0.68; Exp/FE-IVD: R²=0.71, p=0.84). In conclusion, FE-PMMA correlates well with in vitro strength of human vertebral bodies loaded via real IVDs and FE-IVD with hyperelastic IVDs do not significantly improve this correlation. Therefore, it seems not worth adding the IVDs to vertebral body models until fully validated patient-specific IVD models become available.

AB - Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body provide better prediction of vertebral strength than dual energy X-ray absorptiometry. However, most models were validated against compression of vertebral bodies with endplates embedded in polymethylmethalcrylate (PMMA). Yet, loading being as important as bone density, the absence of intervertebral disc (IVD) affects the strength. Accordingly, the aim was to assess the strength predictions of the classic FE models (vertebral body embedded) against the in vitro and in silico strengths of vertebral bodies loaded via IVDs. High resolution peripheral QCT (HR-pQCT) were performed on 13 segments (T11/T12/L1). T11 and L1 were augmented with PMMA and the samples were tested under a 4° wedge compression until failure of T12. Specimen-specific model was generated for each T12 from the HR-pQCT data. Two FE sets were created: FE-PMMA refers to the classical vertebral body embedded model under axial compression; FE-IVD to their loading via hyperelastic IVD model under the wedge compression as conducted experimentally. Results showed that FE-PMMA models overestimated the experimental strength and their strength prediction was satisfactory considering the different experimental set-up. On the other hand, the FE-IVD models did not prove significantly better (Exp/FE-PMMA: R²=0.68; Exp/FE-IVD: R²=0.71, p=0.84). In conclusion, FE-PMMA correlates well with in vitro strength of human vertebral bodies loaded via real IVDs and FE-IVD with hyperelastic IVDs do not significantly improve this correlation. Therefore, it seems not worth adding the IVDs to vertebral body models until fully validated patient-specific IVD models become available.

KW - Absorptiometry, Photon

KW - Adult

KW - Aged

KW - Algorithms

KW - Biomechanical Phenomena

KW - Bone Density

KW - Compressive Strength

KW - Elasticity

KW - Female

KW - Finite Element Analysis

KW - Humans

KW - Intervertebral Disc

KW - Lumbar Vertebrae

KW - Middle Aged

KW - Models, Biological

KW - Models, Statistical

KW - Polymethyl Methacrylate

KW - Spine

KW - Stress, Mechanical

KW - Thoracic Vertebrae

KW - Tomography, X-Ray Computed

U2 - 10.1016/j.jbiomech.2014.04.015

DO - 10.1016/j.jbiomech.2014.04.015

M3 - SCORING: Journal article

C2 - 24818795

VL - 47

SP - 2512

EP - 2516

JO - J BIOMECH

JF - J BIOMECH

SN - 0021-9290

IS - 10

ER -