Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength
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Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength. / Lu, Yongtao; Maquer, Ghislain; Museyko, Oleg; Püschel, Klaus; Engelke, Klaus; Zysset, Philippe; Morlock, Michael; Huber, Gerd.
in: J BIOMECH, Jahrgang 47, Nr. 10, 18.07.2014, S. 2512-2516.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength
AU - Lu, Yongtao
AU - Maquer, Ghislain
AU - Museyko, Oleg
AU - Püschel, Klaus
AU - Engelke, Klaus
AU - Zysset, Philippe
AU - Morlock, Michael
AU - Huber, Gerd
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/7/18
Y1 - 2014/7/18
N2 - Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body provide better prediction of vertebral strength than dual energy X-ray absorptiometry. However, most models were validated against compression of vertebral bodies with endplates embedded in polymethylmethalcrylate (PMMA). Yet, loading being as important as bone density, the absence of intervertebral disc (IVD) affects the strength. Accordingly, the aim was to assess the strength predictions of the classic FE models (vertebral body embedded) against the in vitro and in silico strengths of vertebral bodies loaded via IVDs. High resolution peripheral QCT (HR-pQCT) were performed on 13 segments (T11/T12/L1). T11 and L1 were augmented with PMMA and the samples were tested under a 4° wedge compression until failure of T12. Specimen-specific model was generated for each T12 from the HR-pQCT data. Two FE sets were created: FE-PMMA refers to the classical vertebral body embedded model under axial compression; FE-IVD to their loading via hyperelastic IVD model under the wedge compression as conducted experimentally. Results showed that FE-PMMA models overestimated the experimental strength and their strength prediction was satisfactory considering the different experimental set-up. On the other hand, the FE-IVD models did not prove significantly better (Exp/FE-PMMA: R²=0.68; Exp/FE-IVD: R²=0.71, p=0.84). In conclusion, FE-PMMA correlates well with in vitro strength of human vertebral bodies loaded via real IVDs and FE-IVD with hyperelastic IVDs do not significantly improve this correlation. Therefore, it seems not worth adding the IVDs to vertebral body models until fully validated patient-specific IVD models become available.
AB - Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body provide better prediction of vertebral strength than dual energy X-ray absorptiometry. However, most models were validated against compression of vertebral bodies with endplates embedded in polymethylmethalcrylate (PMMA). Yet, loading being as important as bone density, the absence of intervertebral disc (IVD) affects the strength. Accordingly, the aim was to assess the strength predictions of the classic FE models (vertebral body embedded) against the in vitro and in silico strengths of vertebral bodies loaded via IVDs. High resolution peripheral QCT (HR-pQCT) were performed on 13 segments (T11/T12/L1). T11 and L1 were augmented with PMMA and the samples were tested under a 4° wedge compression until failure of T12. Specimen-specific model was generated for each T12 from the HR-pQCT data. Two FE sets were created: FE-PMMA refers to the classical vertebral body embedded model under axial compression; FE-IVD to their loading via hyperelastic IVD model under the wedge compression as conducted experimentally. Results showed that FE-PMMA models overestimated the experimental strength and their strength prediction was satisfactory considering the different experimental set-up. On the other hand, the FE-IVD models did not prove significantly better (Exp/FE-PMMA: R²=0.68; Exp/FE-IVD: R²=0.71, p=0.84). In conclusion, FE-PMMA correlates well with in vitro strength of human vertebral bodies loaded via real IVDs and FE-IVD with hyperelastic IVDs do not significantly improve this correlation. Therefore, it seems not worth adding the IVDs to vertebral body models until fully validated patient-specific IVD models become available.
KW - Absorptiometry, Photon
KW - Adult
KW - Aged
KW - Algorithms
KW - Biomechanical Phenomena
KW - Bone Density
KW - Compressive Strength
KW - Elasticity
KW - Female
KW - Finite Element Analysis
KW - Humans
KW - Intervertebral Disc
KW - Lumbar Vertebrae
KW - Middle Aged
KW - Models, Biological
KW - Models, Statistical
KW - Polymethyl Methacrylate
KW - Spine
KW - Stress, Mechanical
KW - Thoracic Vertebrae
KW - Tomography, X-Ray Computed
U2 - 10.1016/j.jbiomech.2014.04.015
DO - 10.1016/j.jbiomech.2014.04.015
M3 - SCORING: Journal article
C2 - 24818795
VL - 47
SP - 2512
EP - 2516
JO - J BIOMECH
JF - J BIOMECH
SN - 0021-9290
IS - 10
ER -