FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study
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FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. / Magnussen, Christina; Ojeda, Francisco M; Rzayeva, Nargiz; Zeller, Tanja; Sinning, Christoph R; Pfeiffer, Norbert; Beutel, Manfred; Blettner, Maria; Lackner, Karl J; Blankenberg, Stefan; Münzel, Thomas; Rabe, Klaus F; Wild, Philipp S; Schnabel, Renate B; Gutenberg Health Study investigators.
In: INT J CARDIOL, Vol. 234, 01.05.2017, p. 64-68.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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TY - JOUR
T1 - FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study
AU - Magnussen, Christina
AU - Ojeda, Francisco M
AU - Rzayeva, Nargiz
AU - Zeller, Tanja
AU - Sinning, Christoph R
AU - Pfeiffer, Norbert
AU - Beutel, Manfred
AU - Blettner, Maria
AU - Lackner, Karl J
AU - Blankenberg, Stefan
AU - Münzel, Thomas
AU - Rabe, Klaus F
AU - Wild, Philipp S
AU - Schnabel, Renate B
AU - Gutenberg Health Study investigators
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear.METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis.RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed.CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.
AB - BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear.METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis.RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed.CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.
KW - Adult
KW - Aged
KW - Cardiovascular Diseases/mortality
KW - Cause of Death
KW - Echocardiography/methods
KW - Female
KW - Forced Expiratory Volume/physiology
KW - Humans
KW - Lung/physiopathology
KW - Male
KW - Middle Aged
KW - Mortality
KW - Natriuretic Peptide, Brain/analysis
KW - Peptide Fragments/analysis
KW - Proportional Hazards Models
KW - Risk Factors
KW - Statistics as Topic
KW - Vital Capacity/physiology
U2 - 10.1016/j.ijcard.2017.02.012
DO - 10.1016/j.ijcard.2017.02.012
M3 - SCORING: Journal article
C2 - 28214081
VL - 234
SP - 64
EP - 68
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
ER -