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FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study

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FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. / Magnussen, Christina; Ojeda, Francisco M; Rzayeva, Nargiz; Zeller, Tanja; Sinning, Christoph R; Pfeiffer, Norbert; Beutel, Manfred; Blettner, Maria; Lackner, Karl J; Blankenberg, Stefan; Münzel, Thomas; Rabe, Klaus F; Wild, Philipp S; Schnabel, Renate B; Gutenberg Health Study investigators.

in: INT J CARDIOL, Jahrgang 234, 01.05.2017, S. 64-68.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Magnussen, C, Ojeda, FM, Rzayeva, N, Zeller, T, Sinning, CR, Pfeiffer, N, Beutel, M, Blettner, M, Lackner, KJ, Blankenberg, S, Münzel, T, Rabe, KF, Wild, PS, Schnabel, RB & Gutenberg Health Study investigators 2017, 'FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study', INT J CARDIOL, Jg. 234, S. 64-68. https://doi.org/10.1016/j.ijcard.2017.02.012

APA

Magnussen, C., Ojeda, F. M., Rzayeva, N., Zeller, T., Sinning, C. R., Pfeiffer, N., Beutel, M., Blettner, M., Lackner, K. J., Blankenberg, S., Münzel, T., Rabe, K. F., Wild, P. S., Schnabel, R. B., & Gutenberg Health Study investigators (2017). FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. INT J CARDIOL, 234, 64-68. https://doi.org/10.1016/j.ijcard.2017.02.012

Vancouver

Magnussen C, Ojeda FM, Rzayeva N, Zeller T, Sinning CR, Pfeiffer N et al. FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. INT J CARDIOL. 2017 Mai 1;234:64-68. https://doi.org/10.1016/j.ijcard.2017.02.012

Bibtex

@article{376d1636963543adbce0559089a8f760,
title = "FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study",
abstract = "BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear.METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis.RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed.CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.",
keywords = "Adult, Aged, Cardiovascular Diseases/mortality, Cause of Death, Echocardiography/methods, Female, Forced Expiratory Volume/physiology, Humans, Lung/physiopathology, Male, Middle Aged, Mortality, Natriuretic Peptide, Brain/analysis, Peptide Fragments/analysis, Proportional Hazards Models, Risk Factors, Statistics as Topic, Vital Capacity/physiology",
author = "Christina Magnussen and Ojeda, {Francisco M} and Nargiz Rzayeva and Tanja Zeller and Sinning, {Christoph R} and Norbert Pfeiffer and Manfred Beutel and Maria Blettner and Lackner, {Karl J} and Stefan Blankenberg and Thomas M{\"u}nzel and Rabe, {Klaus F} and Wild, {Philipp S} and Schnabel, {Renate B} and {Gutenberg Health Study investigators}",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = may,
day = "1",
doi = "10.1016/j.ijcard.2017.02.012",
language = "English",
volume = "234",
pages = "64--68",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study

AU - Magnussen, Christina

AU - Ojeda, Francisco M

AU - Rzayeva, Nargiz

AU - Zeller, Tanja

AU - Sinning, Christoph R

AU - Pfeiffer, Norbert

AU - Beutel, Manfred

AU - Blettner, Maria

AU - Lackner, Karl J

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Rabe, Klaus F

AU - Wild, Philipp S

AU - Schnabel, Renate B

AU - Gutenberg Health Study investigators

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear.METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis.RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed.CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.

AB - BACKGROUND: Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear.METHODS: In 15010 individuals from the general population (age range 35-74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis.RESULTS: The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) 94.2% as a percentage of their predicted values. The median FEV1/FVC ratio was 79.1%. In 13191 subjects, 335 deaths were verified from death certificate over a median follow-up of 5.5years. Multivariable-adjusted Cox regression analyses for common cardiovascular risk factors and heart failure revealed that an increase of one standard deviation (SD) of percent predicted (%pred.) FEV1 was associated with a 22% risk reduction (hazard ratio [HR] per SD 0.78 [95% confidence interval (CI): 0.70, 0.86]). The association remained statistically significant after additional adjustment for diastolic dysfunction, Nt-proBNP or hsTnI. Comparable results were seen for %pred. FVC. After adjustment, no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed.CONCLUSIONS: The lung function parameters FEV1 and FVC, but not FEV1/FVC ratio, were related to all-cause mortality in individuals from the general population independent of cardiac function.

KW - Adult

KW - Aged

KW - Cardiovascular Diseases/mortality

KW - Cause of Death

KW - Echocardiography/methods

KW - Female

KW - Forced Expiratory Volume/physiology

KW - Humans

KW - Lung/physiopathology

KW - Male

KW - Middle Aged

KW - Mortality

KW - Natriuretic Peptide, Brain/analysis

KW - Peptide Fragments/analysis

KW - Proportional Hazards Models

KW - Risk Factors

KW - Statistics as Topic

KW - Vital Capacity/physiology

U2 - 10.1016/j.ijcard.2017.02.012

DO - 10.1016/j.ijcard.2017.02.012

M3 - SCORING: Journal article

C2 - 28214081

VL - 234

SP - 64

EP - 68

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -