Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation
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Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation. / Handgretinger, Rupert; Chen, Xiaohua; Pfeiffer, Matthias; Müller, Ingo; Feuchtinger, Tobias; Hale, Gregory A; Lang, Peter.
In: ANN NY ACAD SCI, Vol. 1106, 06.2007, p. 279-89.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation
AU - Handgretinger, Rupert
AU - Chen, Xiaohua
AU - Pfeiffer, Matthias
AU - Müller, Ingo
AU - Feuchtinger, Tobias
AU - Hale, Gregory A
AU - Lang, Peter
PY - 2007/6
Y1 - 2007/6
N2 - Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical-related or -unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34(+) positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.
AB - Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical-related or -unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34(+) positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.
KW - Antigens, CD3
KW - Antigens, CD34
KW - B-Lymphocytes
KW - Feasibility Studies
KW - Graft Survival
KW - Graft vs Host Disease
KW - HLA Antigens
KW - Histocompatibility Testing
KW - Humans
KW - Immune System
KW - Recurrence
KW - Stem Cell Transplantation
KW - T-Lymphocytes
KW - Transplantation Conditioning
KW - Transplantation, Homologous
U2 - 10.1196/annals.1392.022
DO - 10.1196/annals.1392.022
M3 - SCORING: Journal article
C2 - 17442774
VL - 1106
SP - 279
EP - 289
JO - ANN NY ACAD SCI
JF - ANN NY ACAD SCI
SN - 0077-8923
ER -