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Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation

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Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation. / Handgretinger, Rupert; Chen, Xiaohua; Pfeiffer, Matthias; Müller, Ingo; Feuchtinger, Tobias; Hale, Gregory A; Lang, Peter.

in: ANN NY ACAD SCI, Jahrgang 1106, 06.2007, S. 279-89.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Handgretinger, R, Chen, X, Pfeiffer, M, Müller, I, Feuchtinger, T, Hale, GA & Lang, P 2007, 'Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation', ANN NY ACAD SCI, Jg. 1106, S. 279-89. https://doi.org/10.1196/annals.1392.022

APA

Handgretinger, R., Chen, X., Pfeiffer, M., Müller, I., Feuchtinger, T., Hale, G. A., & Lang, P. (2007). Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation. ANN NY ACAD SCI, 1106, 279-89. https://doi.org/10.1196/annals.1392.022

Vancouver

Handgretinger R, Chen X, Pfeiffer M, Müller I, Feuchtinger T, Hale GA et al. Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation. ANN NY ACAD SCI. 2007 Jun;1106:279-89. https://doi.org/10.1196/annals.1392.022

Bibtex

@article{3075a86ddb4a4feb82a7eda406f0e4fa,
title = "Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation",
abstract = "Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical-related or -unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34(+) positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.",
keywords = "Antigens, CD3, Antigens, CD34, B-Lymphocytes, Feasibility Studies, Graft Survival, Graft vs Host Disease, HLA Antigens, Histocompatibility Testing, Humans, Immune System, Recurrence, Stem Cell Transplantation, T-Lymphocytes, Transplantation Conditioning, Transplantation, Homologous",
author = "Rupert Handgretinger and Xiaohua Chen and Matthias Pfeiffer and Ingo M{\"u}ller and Tobias Feuchtinger and Hale, {Gregory A} and Peter Lang",
year = "2007",
month = jun,
doi = "10.1196/annals.1392.022",
language = "English",
volume = "1106",
pages = "279--89",
journal = "ANN NY ACAD SCI",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation

AU - Handgretinger, Rupert

AU - Chen, Xiaohua

AU - Pfeiffer, Matthias

AU - Müller, Ingo

AU - Feuchtinger, Tobias

AU - Hale, Gregory A

AU - Lang, Peter

PY - 2007/6

Y1 - 2007/6

N2 - Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical-related or -unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34(+) positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.

AB - Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical-related or -unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34(+) positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.

KW - Antigens, CD3

KW - Antigens, CD34

KW - B-Lymphocytes

KW - Feasibility Studies

KW - Graft Survival

KW - Graft vs Host Disease

KW - HLA Antigens

KW - Histocompatibility Testing

KW - Humans

KW - Immune System

KW - Recurrence

KW - Stem Cell Transplantation

KW - T-Lymphocytes

KW - Transplantation Conditioning

KW - Transplantation, Homologous

U2 - 10.1196/annals.1392.022

DO - 10.1196/annals.1392.022

M3 - SCORING: Journal article

C2 - 17442774

VL - 1106

SP - 279

EP - 289

JO - ANN NY ACAD SCI

JF - ANN NY ACAD SCI

SN - 0077-8923

ER -