FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
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FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. / Ricklefs, Franz L; Maire, Cecile L; Matschke, Jakob; Dührsen, Lasse; Sauvigny, Thomas; Holz, Mareike; Kolbe, Katharina; Peine, Sven; Herold-Mende, Christel; Carter, Bob; Chiocca, E Antonio; Lawler, Sean E; Westphal, Manfred; Lamszus, Katrin.
In: INT J MOL SCI, Vol. 21, No. 6, 12.03.2020.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles
AU - Ricklefs, Franz L
AU - Maire, Cecile L
AU - Matschke, Jakob
AU - Dührsen, Lasse
AU - Sauvigny, Thomas
AU - Holz, Mareike
AU - Kolbe, Katharina
AU - Peine, Sven
AU - Herold-Mende, Christel
AU - Carter, Bob
AU - Chiocca, E Antonio
AU - Lawler, Sean E
AU - Westphal, Manfred
AU - Lamszus, Katrin
PY - 2020/3/12
Y1 - 2020/3/12
N2 - Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
AB - Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
U2 - 10.3390/ijms21061931
DO - 10.3390/ijms21061931
M3 - SCORING: Journal article
C2 - 32178271
VL - 21
JO - INT J MOL SCI
JF - INT J MOL SCI
SN - 1661-6596
IS - 6
ER -