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FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles

Standard

FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. / Ricklefs, Franz L; Maire, Cecile L; Matschke, Jakob; Dührsen, Lasse; Sauvigny, Thomas; Holz, Mareike; Kolbe, Katharina; Peine, Sven; Herold-Mende, Christel; Carter, Bob; Chiocca, E Antonio; Lawler, Sean E; Westphal, Manfred; Lamszus, Katrin.

in: INT J MOL SCI, Jahrgang 21, Nr. 6, 12.03.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ricklefs, FL, Maire, CL, Matschke, J, Dührsen, L, Sauvigny, T, Holz, M, Kolbe, K, Peine, S, Herold-Mende, C, Carter, B, Chiocca, EA, Lawler, SE, Westphal, M & Lamszus, K 2020, 'FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles', INT J MOL SCI, Jg. 21, Nr. 6. https://doi.org/10.3390/ijms21061931

APA

Ricklefs, F. L., Maire, C. L., Matschke, J., Dührsen, L., Sauvigny, T., Holz, M., Kolbe, K., Peine, S., Herold-Mende, C., Carter, B., Chiocca, E. A., Lawler, S. E., Westphal, M., & Lamszus, K. (2020). FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. INT J MOL SCI, 21(6). https://doi.org/10.3390/ijms21061931

Vancouver

Ricklefs FL, Maire CL, Matschke J, Dührsen L, Sauvigny T, Holz M et al. FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. INT J MOL SCI. 2020 Mär 12;21(6). https://doi.org/10.3390/ijms21061931

Bibtex

@article{32e77199571d4cd6b269f638c82ed51f,
title = "FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles",
abstract = "Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.",
author = "Ricklefs, {Franz L} and Maire, {Cecile L} and Jakob Matschke and Lasse D{\"u}hrsen and Thomas Sauvigny and Mareike Holz and Katharina Kolbe and Sven Peine and Christel Herold-Mende and Bob Carter and Chiocca, {E Antonio} and Lawler, {Sean E} and Manfred Westphal and Katrin Lamszus",
year = "2020",
month = mar,
day = "12",
doi = "10.3390/ijms21061931",
language = "English",
volume = "21",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",

}

RIS

TY - JOUR

T1 - FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles

AU - Ricklefs, Franz L

AU - Maire, Cecile L

AU - Matschke, Jakob

AU - Dührsen, Lasse

AU - Sauvigny, Thomas

AU - Holz, Mareike

AU - Kolbe, Katharina

AU - Peine, Sven

AU - Herold-Mende, Christel

AU - Carter, Bob

AU - Chiocca, E Antonio

AU - Lawler, Sean E

AU - Westphal, Manfred

AU - Lamszus, Katrin

PY - 2020/3/12

Y1 - 2020/3/12

N2 - Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.

AB - Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.

U2 - 10.3390/ijms21061931

DO - 10.3390/ijms21061931

M3 - SCORING: Journal article

C2 - 32178271

VL - 21

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 6

ER -