Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice.
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Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. / Jansen, B; Heere-Ress, E; Schlagbauer-Wadl, H; Halaschek-Wiener, J; Waltering, S; Moll, Ingrid; Pehamberger, H; Marciano, D; Kloog, Y; Wolff, K.
In: J MOL MED, Vol. 77, No. 11, 11, 1999, p. 792-797.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice.
AU - Jansen, B
AU - Heere-Ress, E
AU - Schlagbauer-Wadl, H
AU - Halaschek-Wiener, J
AU - Waltering, S
AU - Moll, Ingrid
AU - Pehamberger, H
AU - Marciano, D
AU - Kloog, Y
AU - Wolff, K
PY - 1999
Y1 - 1999
N2 - Merkel cell carcinoma (MCC) is a neuroendocrine malignancy showing poor response to a variety of therapeutic strategies. We evaluated the antitumor activity of S-trans, trans-farnesylthiosalicylic acid (FTS), a new inhibitor of Ras signal transduction, in a newly established SCID mouse xenotransplantation model for human MCC (seven animals per group). FTS injected intraperitoneally at 5 mg/kg per day for 2 weeks up-regulated the tumor suppressor p53 and induced tumor cell apoptosis in established MCCs growing subcutaneously in SCID mice. These effects led to a statistically significant inhibition of MCC growth (P
AB - Merkel cell carcinoma (MCC) is a neuroendocrine malignancy showing poor response to a variety of therapeutic strategies. We evaluated the antitumor activity of S-trans, trans-farnesylthiosalicylic acid (FTS), a new inhibitor of Ras signal transduction, in a newly established SCID mouse xenotransplantation model for human MCC (seven animals per group). FTS injected intraperitoneally at 5 mg/kg per day for 2 weeks up-regulated the tumor suppressor p53 and induced tumor cell apoptosis in established MCCs growing subcutaneously in SCID mice. These effects led to a statistically significant inhibition of MCC growth (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 77
SP - 792
EP - 797
JO - J MOL MED
JF - J MOL MED
SN - 0946-2716
IS - 11
M1 - 11
ER -