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Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice.

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Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. / Jansen, B; Heere-Ress, E; Schlagbauer-Wadl, H; Halaschek-Wiener, J; Waltering, S; Moll, Ingrid; Pehamberger, H; Marciano, D; Kloog, Y; Wolff, K.

in: J MOL MED, Jahrgang 77, Nr. 11, 11, 1999, S. 792-797.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jansen, B, Heere-Ress, E, Schlagbauer-Wadl, H, Halaschek-Wiener, J, Waltering, S, Moll, I, Pehamberger, H, Marciano, D, Kloog, Y & Wolff, K 1999, 'Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice.', J MOL MED, Jg. 77, Nr. 11, 11, S. 792-797. <http://www.ncbi.nlm.nih.gov/pubmed/10619439?dopt=Citation>

APA

Jansen, B., Heere-Ress, E., Schlagbauer-Wadl, H., Halaschek-Wiener, J., Waltering, S., Moll, I., Pehamberger, H., Marciano, D., Kloog, Y., & Wolff, K. (1999). Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. J MOL MED, 77(11), 792-797. [11]. http://www.ncbi.nlm.nih.gov/pubmed/10619439?dopt=Citation

Vancouver

Jansen B, Heere-Ress E, Schlagbauer-Wadl H, Halaschek-Wiener J, Waltering S, Moll I et al. Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice. J MOL MED. 1999;77(11):792-797. 11.

Bibtex

@article{5b03e69a2fd047868bbd3ea44644a34e,
title = "Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice.",
abstract = "Merkel cell carcinoma (MCC) is a neuroendocrine malignancy showing poor response to a variety of therapeutic strategies. We evaluated the antitumor activity of S-trans, trans-farnesylthiosalicylic acid (FTS), a new inhibitor of Ras signal transduction, in a newly established SCID mouse xenotransplantation model for human MCC (seven animals per group). FTS injected intraperitoneally at 5 mg/kg per day for 2 weeks up-regulated the tumor suppressor p53 and induced tumor cell apoptosis in established MCCs growing subcutaneously in SCID mice. These effects led to a statistically significant inhibition of MCC growth (P",
author = "B Jansen and E Heere-Ress and H Schlagbauer-Wadl and J Halaschek-Wiener and S Waltering and Ingrid Moll and H Pehamberger and D Marciano and Y Kloog and K Wolff",
year = "1999",
language = "Deutsch",
volume = "77",
pages = "792--797",
journal = "J MOL MED",
issn = "0946-2716",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Farnesylthiosalicylic acid inhibits the growth of human Merkel cell carcinoma in SCID mice.

AU - Jansen, B

AU - Heere-Ress, E

AU - Schlagbauer-Wadl, H

AU - Halaschek-Wiener, J

AU - Waltering, S

AU - Moll, Ingrid

AU - Pehamberger, H

AU - Marciano, D

AU - Kloog, Y

AU - Wolff, K

PY - 1999

Y1 - 1999

N2 - Merkel cell carcinoma (MCC) is a neuroendocrine malignancy showing poor response to a variety of therapeutic strategies. We evaluated the antitumor activity of S-trans, trans-farnesylthiosalicylic acid (FTS), a new inhibitor of Ras signal transduction, in a newly established SCID mouse xenotransplantation model for human MCC (seven animals per group). FTS injected intraperitoneally at 5 mg/kg per day for 2 weeks up-regulated the tumor suppressor p53 and induced tumor cell apoptosis in established MCCs growing subcutaneously in SCID mice. These effects led to a statistically significant inhibition of MCC growth (P

AB - Merkel cell carcinoma (MCC) is a neuroendocrine malignancy showing poor response to a variety of therapeutic strategies. We evaluated the antitumor activity of S-trans, trans-farnesylthiosalicylic acid (FTS), a new inhibitor of Ras signal transduction, in a newly established SCID mouse xenotransplantation model for human MCC (seven animals per group). FTS injected intraperitoneally at 5 mg/kg per day for 2 weeks up-regulated the tumor suppressor p53 and induced tumor cell apoptosis in established MCCs growing subcutaneously in SCID mice. These effects led to a statistically significant inhibition of MCC growth (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 77

SP - 792

EP - 797

JO - J MOL MED

JF - J MOL MED

SN - 0946-2716

IS - 11

M1 - 11

ER -