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Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas

Standard

Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas. / Grupp, Katharina; Melling, Nathaniel; Bogoevska, Valentina; Reeh, Matthias; Uzunoglu, Faik Güntac; El Gammal, Alexander Tarek; Nentwich, Michael Fabian; Izbicki, Jakob Robert; Bogoevski, Dean.

In: EXP MOL PATHOL, Vol. 104, No. 2, 04.2018, p. 109-113.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grupp, K, Melling, N, Bogoevska, V, Reeh, M, Uzunoglu, FG, El Gammal, AT, Nentwich, MF, Izbicki, JR & Bogoevski, D 2018, 'Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas', EXP MOL PATHOL, vol. 104, no. 2, pp. 109-113. https://doi.org/10.1016/j.yexmp.2018.01.005

APA

Grupp, K., Melling, N., Bogoevska, V., Reeh, M., Uzunoglu, F. G., El Gammal, A. T., Nentwich, M. F., Izbicki, J. R., & Bogoevski, D. (2018). Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas. EXP MOL PATHOL, 104(2), 109-113. https://doi.org/10.1016/j.yexmp.2018.01.005

Vancouver

Grupp K, Melling N, Bogoevska V, Reeh M, Uzunoglu FG, El Gammal AT et al. Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas. EXP MOL PATHOL. 2018 Apr;104(2):109-113. https://doi.org/10.1016/j.yexmp.2018.01.005

Bibtex

@article{42393bc1f14842ce8528e4fcaa056eab,
title = "Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas",
abstract = "Development and progression of malignant tumors is in part characterized by the ability of a tumor cell to overcome cell-cell and cell-matrix adhesion and to disseminate in organs distinct from that in which they originated. This study was undertaken to analyze the clinical significance of the expression of the following cell-cell and cell-matrix adhesion molecules in pancreatic ductal adenocarcinomas (PDACs) and synchronous liver metastases: intercellular adhesion molecule 1 (ICAM-1), E-cadherin, periostin, and midkine (MK). ICAM-1, E-cadherin, periostin and MK expression was analyzed by immunohistochemistry on a tissue microarray containing 34 PDACs and 12 liver metastasis specimens. ICAM-1 expression was predominantly localized in the membranes of the cells and was found in weak to moderate intensities in PDACs and liver metastases. E-cadherin expression was absent in the majority of PDACs and corresponding liver metastases. The secreted proteins periostin and MK were expressed in various intensities in primary cancers and liver metastases. Statistical analysis demonstrated that the expression levels of the analyzed markers were neither significantly associated with metastasis in PDACs nor with clinical outcome of patients. Our study shows that the expression of the cell-cell and cell-matrix adhesion molecules ICAM-1, E-cadherin, periostin and MK was not significantly linked to metastatic disease in PDACs. Moreover, our study excludes the analyzed markers as prognostic markers in PDACs.",
keywords = "Antigens, CD, Biomarkers, Tumor/metabolism, Cadherins/metabolism, Carcinoma, Pancreatic Ductal/metabolism, Cell Adhesion Molecules/metabolism, Humans, Intercellular Adhesion Molecule-1/metabolism, Intercellular Signaling Peptides and Proteins/metabolism, Liver Neoplasms/metabolism, Midkine, Pancreatic Neoplasms/metabolism",
author = "Katharina Grupp and Nathaniel Melling and Valentina Bogoevska and Matthias Reeh and Uzunoglu, {Faik G{\"u}ntac} and {El Gammal}, {Alexander Tarek} and Nentwich, {Michael Fabian} and Izbicki, {Jakob Robert} and Dean Bogoevski",
note = "Copyright {\textcopyright} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = apr,
doi = "10.1016/j.yexmp.2018.01.005",
language = "English",
volume = "104",
pages = "109--113",
journal = "EXP MOL PATHOL",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas

AU - Grupp, Katharina

AU - Melling, Nathaniel

AU - Bogoevska, Valentina

AU - Reeh, Matthias

AU - Uzunoglu, Faik Güntac

AU - El Gammal, Alexander Tarek

AU - Nentwich, Michael Fabian

AU - Izbicki, Jakob Robert

AU - Bogoevski, Dean

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/4

Y1 - 2018/4

N2 - Development and progression of malignant tumors is in part characterized by the ability of a tumor cell to overcome cell-cell and cell-matrix adhesion and to disseminate in organs distinct from that in which they originated. This study was undertaken to analyze the clinical significance of the expression of the following cell-cell and cell-matrix adhesion molecules in pancreatic ductal adenocarcinomas (PDACs) and synchronous liver metastases: intercellular adhesion molecule 1 (ICAM-1), E-cadherin, periostin, and midkine (MK). ICAM-1, E-cadherin, periostin and MK expression was analyzed by immunohistochemistry on a tissue microarray containing 34 PDACs and 12 liver metastasis specimens. ICAM-1 expression was predominantly localized in the membranes of the cells and was found in weak to moderate intensities in PDACs and liver metastases. E-cadherin expression was absent in the majority of PDACs and corresponding liver metastases. The secreted proteins periostin and MK were expressed in various intensities in primary cancers and liver metastases. Statistical analysis demonstrated that the expression levels of the analyzed markers were neither significantly associated with metastasis in PDACs nor with clinical outcome of patients. Our study shows that the expression of the cell-cell and cell-matrix adhesion molecules ICAM-1, E-cadherin, periostin and MK was not significantly linked to metastatic disease in PDACs. Moreover, our study excludes the analyzed markers as prognostic markers in PDACs.

AB - Development and progression of malignant tumors is in part characterized by the ability of a tumor cell to overcome cell-cell and cell-matrix adhesion and to disseminate in organs distinct from that in which they originated. This study was undertaken to analyze the clinical significance of the expression of the following cell-cell and cell-matrix adhesion molecules in pancreatic ductal adenocarcinomas (PDACs) and synchronous liver metastases: intercellular adhesion molecule 1 (ICAM-1), E-cadherin, periostin, and midkine (MK). ICAM-1, E-cadherin, periostin and MK expression was analyzed by immunohistochemistry on a tissue microarray containing 34 PDACs and 12 liver metastasis specimens. ICAM-1 expression was predominantly localized in the membranes of the cells and was found in weak to moderate intensities in PDACs and liver metastases. E-cadherin expression was absent in the majority of PDACs and corresponding liver metastases. The secreted proteins periostin and MK were expressed in various intensities in primary cancers and liver metastases. Statistical analysis demonstrated that the expression levels of the analyzed markers were neither significantly associated with metastasis in PDACs nor with clinical outcome of patients. Our study shows that the expression of the cell-cell and cell-matrix adhesion molecules ICAM-1, E-cadherin, periostin and MK was not significantly linked to metastatic disease in PDACs. Moreover, our study excludes the analyzed markers as prognostic markers in PDACs.

KW - Antigens, CD

KW - Biomarkers, Tumor/metabolism

KW - Cadherins/metabolism

KW - Carcinoma, Pancreatic Ductal/metabolism

KW - Cell Adhesion Molecules/metabolism

KW - Humans

KW - Intercellular Adhesion Molecule-1/metabolism

KW - Intercellular Signaling Peptides and Proteins/metabolism

KW - Liver Neoplasms/metabolism

KW - Midkine

KW - Pancreatic Neoplasms/metabolism

U2 - 10.1016/j.yexmp.2018.01.005

DO - 10.1016/j.yexmp.2018.01.005

M3 - SCORING: Journal article

C2 - 29355490

VL - 104

SP - 109

EP - 113

JO - EXP MOL PATHOL

JF - EXP MOL PATHOL

SN - 0014-4800

IS - 2

ER -