Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas
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Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas. / Grupp, Katharina; Melling, Nathaniel; Bogoevska, Valentina; Reeh, Matthias; Uzunoglu, Faik Güntac; El Gammal, Alexander Tarek; Nentwich, Michael Fabian; Izbicki, Jakob Robert; Bogoevski, Dean.
in: EXP MOL PATHOL, Jahrgang 104, Nr. 2, 04.2018, S. 109-113.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Expression of ICAM-1, E-cadherin, periostin and midkine in metastases of pancreatic ductal adenocarcinomas
AU - Grupp, Katharina
AU - Melling, Nathaniel
AU - Bogoevska, Valentina
AU - Reeh, Matthias
AU - Uzunoglu, Faik Güntac
AU - El Gammal, Alexander Tarek
AU - Nentwich, Michael Fabian
AU - Izbicki, Jakob Robert
AU - Bogoevski, Dean
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Development and progression of malignant tumors is in part characterized by the ability of a tumor cell to overcome cell-cell and cell-matrix adhesion and to disseminate in organs distinct from that in which they originated. This study was undertaken to analyze the clinical significance of the expression of the following cell-cell and cell-matrix adhesion molecules in pancreatic ductal adenocarcinomas (PDACs) and synchronous liver metastases: intercellular adhesion molecule 1 (ICAM-1), E-cadherin, periostin, and midkine (MK). ICAM-1, E-cadherin, periostin and MK expression was analyzed by immunohistochemistry on a tissue microarray containing 34 PDACs and 12 liver metastasis specimens. ICAM-1 expression was predominantly localized in the membranes of the cells and was found in weak to moderate intensities in PDACs and liver metastases. E-cadherin expression was absent in the majority of PDACs and corresponding liver metastases. The secreted proteins periostin and MK were expressed in various intensities in primary cancers and liver metastases. Statistical analysis demonstrated that the expression levels of the analyzed markers were neither significantly associated with metastasis in PDACs nor with clinical outcome of patients. Our study shows that the expression of the cell-cell and cell-matrix adhesion molecules ICAM-1, E-cadherin, periostin and MK was not significantly linked to metastatic disease in PDACs. Moreover, our study excludes the analyzed markers as prognostic markers in PDACs.
AB - Development and progression of malignant tumors is in part characterized by the ability of a tumor cell to overcome cell-cell and cell-matrix adhesion and to disseminate in organs distinct from that in which they originated. This study was undertaken to analyze the clinical significance of the expression of the following cell-cell and cell-matrix adhesion molecules in pancreatic ductal adenocarcinomas (PDACs) and synchronous liver metastases: intercellular adhesion molecule 1 (ICAM-1), E-cadherin, periostin, and midkine (MK). ICAM-1, E-cadherin, periostin and MK expression was analyzed by immunohistochemistry on a tissue microarray containing 34 PDACs and 12 liver metastasis specimens. ICAM-1 expression was predominantly localized in the membranes of the cells and was found in weak to moderate intensities in PDACs and liver metastases. E-cadherin expression was absent in the majority of PDACs and corresponding liver metastases. The secreted proteins periostin and MK were expressed in various intensities in primary cancers and liver metastases. Statistical analysis demonstrated that the expression levels of the analyzed markers were neither significantly associated with metastasis in PDACs nor with clinical outcome of patients. Our study shows that the expression of the cell-cell and cell-matrix adhesion molecules ICAM-1, E-cadherin, periostin and MK was not significantly linked to metastatic disease in PDACs. Moreover, our study excludes the analyzed markers as prognostic markers in PDACs.
KW - Antigens, CD
KW - Biomarkers, Tumor/metabolism
KW - Cadherins/metabolism
KW - Carcinoma, Pancreatic Ductal/metabolism
KW - Cell Adhesion Molecules/metabolism
KW - Humans
KW - Intercellular Adhesion Molecule-1/metabolism
KW - Intercellular Signaling Peptides and Proteins/metabolism
KW - Liver Neoplasms/metabolism
KW - Midkine
KW - Pancreatic Neoplasms/metabolism
U2 - 10.1016/j.yexmp.2018.01.005
DO - 10.1016/j.yexmp.2018.01.005
M3 - SCORING: Journal article
C2 - 29355490
VL - 104
SP - 109
EP - 113
JO - EXP MOL PATHOL
JF - EXP MOL PATHOL
SN - 0014-4800
IS - 2
ER -