Evidence for an agitated-aggressive syndrome predating the onset of psychosis
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Evidence for an agitated-aggressive syndrome predating the onset of psychosis. / Huber, Christian G; Smieskova, Renata; Schroeder, Katrin; Studerus, Erich; Harrisberger, Fabienne; Aston, Jacqueline; Walter, Anna; Walter, Marc; Riecher-Rössler, Anita; Borgwardt, Stefan.
In: SCHIZOPHR RES, Vol. 157, No. 1-3, 01.08.2014, p. 26-32.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Evidence for an agitated-aggressive syndrome predating the onset of psychosis
AU - Huber, Christian G
AU - Smieskova, Renata
AU - Schroeder, Katrin
AU - Studerus, Erich
AU - Harrisberger, Fabienne
AU - Aston, Jacqueline
AU - Walter, Anna
AU - Walter, Marc
AU - Riecher-Rössler, Anita
AU - Borgwardt, Stefan
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/8/1
Y1 - 2014/8/1
N2 - BACKGROUND: Aggression and suicidality prior to the initiation of treatment are frequent phenomena in psychosis patients. Increased scores in the Brief Psychiatric Rating Scale Excited Component (BPRS-EC) have been shown to predict involuntary treatment, aggression, and suicide in first-episode psychosis (FEP) patients. However, it is unclear if an agitated-aggressive syndrome as measured with the BPRS-EC is already present in at-risk mental state (ARMS).METHODS: BPRS-EC scores from 43 ARMS patients, 50 FEP patients, and 25 healthy controls (HC) were analyzed. Multivariate analyses were performed to review if group differences were mediated by potential confounders. In addition, the association of BPRS-EC scores with clinical variables was examined.RESULTS: BPRS-EC scores were significantly different across diagnostic groups (H(2)=22.1; p<.001), and post-hoc analyses showed significantly higher BPRS-EC scores for ARMS (p=.001) and for FEP patients (p<.001) compared to HC. Differences remained significant after controlling for gender, years of education, and intelligence. No significant differences emerged between ARMS and FEP patients. BPRS-EC was significantly correlated with lower intelligence (r=-.27; p=.008), reduced level of functioning (r=-.44; p<.001), and with smoking behavior (r=.22; p=.019).CONCLUSIONS: ARMS and FEP patients in our sample had significantly higher BPRS-EC scores compared to HC. This may constitute a correlate of an agitated-aggressive syndrome and an increased risk for aggression and suicidality.
AB - BACKGROUND: Aggression and suicidality prior to the initiation of treatment are frequent phenomena in psychosis patients. Increased scores in the Brief Psychiatric Rating Scale Excited Component (BPRS-EC) have been shown to predict involuntary treatment, aggression, and suicide in first-episode psychosis (FEP) patients. However, it is unclear if an agitated-aggressive syndrome as measured with the BPRS-EC is already present in at-risk mental state (ARMS).METHODS: BPRS-EC scores from 43 ARMS patients, 50 FEP patients, and 25 healthy controls (HC) were analyzed. Multivariate analyses were performed to review if group differences were mediated by potential confounders. In addition, the association of BPRS-EC scores with clinical variables was examined.RESULTS: BPRS-EC scores were significantly different across diagnostic groups (H(2)=22.1; p<.001), and post-hoc analyses showed significantly higher BPRS-EC scores for ARMS (p=.001) and for FEP patients (p<.001) compared to HC. Differences remained significant after controlling for gender, years of education, and intelligence. No significant differences emerged between ARMS and FEP patients. BPRS-EC was significantly correlated with lower intelligence (r=-.27; p=.008), reduced level of functioning (r=-.44; p<.001), and with smoking behavior (r=.22; p=.019).CONCLUSIONS: ARMS and FEP patients in our sample had significantly higher BPRS-EC scores compared to HC. This may constitute a correlate of an agitated-aggressive syndrome and an increased risk for aggression and suicidality.
KW - Adolescent
KW - Adult
KW - Aggression
KW - Brief Psychiatric Rating Scale
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Mental Disorders
KW - Middle Aged
KW - Multivariate Analysis
KW - Prodromal Symptoms
KW - Psychomotor Agitation
KW - Psychotic Disorders
KW - Risk
KW - Suicide
KW - Syndrome
KW - Young Adult
U2 - 10.1016/j.schres.2014.06.014
DO - 10.1016/j.schres.2014.06.014
M3 - SCORING: Journal article
C2 - 24996505
VL - 157
SP - 26
EP - 32
JO - SCHIZOPHR RES
JF - SCHIZOPHR RES
SN - 0920-9964
IS - 1-3
ER -