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Evidence for an agitated-aggressive syndrome predating the onset of psychosis

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Evidence for an agitated-aggressive syndrome predating the onset of psychosis. / Huber, Christian G; Smieskova, Renata; Schroeder, Katrin; Studerus, Erich; Harrisberger, Fabienne; Aston, Jacqueline; Walter, Anna; Walter, Marc; Riecher-Rössler, Anita; Borgwardt, Stefan.

in: SCHIZOPHR RES, Jahrgang 157, Nr. 1-3, 01.08.2014, S. 26-32.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Huber, CG, Smieskova, R, Schroeder, K, Studerus, E, Harrisberger, F, Aston, J, Walter, A, Walter, M, Riecher-Rössler, A & Borgwardt, S 2014, 'Evidence for an agitated-aggressive syndrome predating the onset of psychosis', SCHIZOPHR RES, Jg. 157, Nr. 1-3, S. 26-32. https://doi.org/10.1016/j.schres.2014.06.014

APA

Huber, C. G., Smieskova, R., Schroeder, K., Studerus, E., Harrisberger, F., Aston, J., Walter, A., Walter, M., Riecher-Rössler, A., & Borgwardt, S. (2014). Evidence for an agitated-aggressive syndrome predating the onset of psychosis. SCHIZOPHR RES, 157(1-3), 26-32. https://doi.org/10.1016/j.schres.2014.06.014

Vancouver

Huber CG, Smieskova R, Schroeder K, Studerus E, Harrisberger F, Aston J et al. Evidence for an agitated-aggressive syndrome predating the onset of psychosis. SCHIZOPHR RES. 2014 Aug 1;157(1-3):26-32. https://doi.org/10.1016/j.schres.2014.06.014

Bibtex

@article{2531ca0327a341e88d4a478638a7508b,
title = "Evidence for an agitated-aggressive syndrome predating the onset of psychosis",
abstract = "BACKGROUND: Aggression and suicidality prior to the initiation of treatment are frequent phenomena in psychosis patients. Increased scores in the Brief Psychiatric Rating Scale Excited Component (BPRS-EC) have been shown to predict involuntary treatment, aggression, and suicide in first-episode psychosis (FEP) patients. However, it is unclear if an agitated-aggressive syndrome as measured with the BPRS-EC is already present in at-risk mental state (ARMS).METHODS: BPRS-EC scores from 43 ARMS patients, 50 FEP patients, and 25 healthy controls (HC) were analyzed. Multivariate analyses were performed to review if group differences were mediated by potential confounders. In addition, the association of BPRS-EC scores with clinical variables was examined.RESULTS: BPRS-EC scores were significantly different across diagnostic groups (H(2)=22.1; p<.001), and post-hoc analyses showed significantly higher BPRS-EC scores for ARMS (p=.001) and for FEP patients (p<.001) compared to HC. Differences remained significant after controlling for gender, years of education, and intelligence. No significant differences emerged between ARMS and FEP patients. BPRS-EC was significantly correlated with lower intelligence (r=-.27; p=.008), reduced level of functioning (r=-.44; p<.001), and with smoking behavior (r=.22; p=.019).CONCLUSIONS: ARMS and FEP patients in our sample had significantly higher BPRS-EC scores compared to HC. This may constitute a correlate of an agitated-aggressive syndrome and an increased risk for aggression and suicidality.",
keywords = "Adolescent, Adult, Aggression, Brief Psychiatric Rating Scale, Female, Humans, Longitudinal Studies, Male, Mental Disorders, Middle Aged, Multivariate Analysis, Prodromal Symptoms, Psychomotor Agitation, Psychotic Disorders, Risk, Suicide, Syndrome, Young Adult",
author = "Huber, {Christian G} and Renata Smieskova and Katrin Schroeder and Erich Studerus and Fabienne Harrisberger and Jacqueline Aston and Anna Walter and Marc Walter and Anita Riecher-R{\"o}ssler and Stefan Borgwardt",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = aug,
day = "1",
doi = "10.1016/j.schres.2014.06.014",
language = "English",
volume = "157",
pages = "26--32",
journal = "SCHIZOPHR RES",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Evidence for an agitated-aggressive syndrome predating the onset of psychosis

AU - Huber, Christian G

AU - Smieskova, Renata

AU - Schroeder, Katrin

AU - Studerus, Erich

AU - Harrisberger, Fabienne

AU - Aston, Jacqueline

AU - Walter, Anna

AU - Walter, Marc

AU - Riecher-Rössler, Anita

AU - Borgwardt, Stefan

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - BACKGROUND: Aggression and suicidality prior to the initiation of treatment are frequent phenomena in psychosis patients. Increased scores in the Brief Psychiatric Rating Scale Excited Component (BPRS-EC) have been shown to predict involuntary treatment, aggression, and suicide in first-episode psychosis (FEP) patients. However, it is unclear if an agitated-aggressive syndrome as measured with the BPRS-EC is already present in at-risk mental state (ARMS).METHODS: BPRS-EC scores from 43 ARMS patients, 50 FEP patients, and 25 healthy controls (HC) were analyzed. Multivariate analyses were performed to review if group differences were mediated by potential confounders. In addition, the association of BPRS-EC scores with clinical variables was examined.RESULTS: BPRS-EC scores were significantly different across diagnostic groups (H(2)=22.1; p<.001), and post-hoc analyses showed significantly higher BPRS-EC scores for ARMS (p=.001) and for FEP patients (p<.001) compared to HC. Differences remained significant after controlling for gender, years of education, and intelligence. No significant differences emerged between ARMS and FEP patients. BPRS-EC was significantly correlated with lower intelligence (r=-.27; p=.008), reduced level of functioning (r=-.44; p<.001), and with smoking behavior (r=.22; p=.019).CONCLUSIONS: ARMS and FEP patients in our sample had significantly higher BPRS-EC scores compared to HC. This may constitute a correlate of an agitated-aggressive syndrome and an increased risk for aggression and suicidality.

AB - BACKGROUND: Aggression and suicidality prior to the initiation of treatment are frequent phenomena in psychosis patients. Increased scores in the Brief Psychiatric Rating Scale Excited Component (BPRS-EC) have been shown to predict involuntary treatment, aggression, and suicide in first-episode psychosis (FEP) patients. However, it is unclear if an agitated-aggressive syndrome as measured with the BPRS-EC is already present in at-risk mental state (ARMS).METHODS: BPRS-EC scores from 43 ARMS patients, 50 FEP patients, and 25 healthy controls (HC) were analyzed. Multivariate analyses were performed to review if group differences were mediated by potential confounders. In addition, the association of BPRS-EC scores with clinical variables was examined.RESULTS: BPRS-EC scores were significantly different across diagnostic groups (H(2)=22.1; p<.001), and post-hoc analyses showed significantly higher BPRS-EC scores for ARMS (p=.001) and for FEP patients (p<.001) compared to HC. Differences remained significant after controlling for gender, years of education, and intelligence. No significant differences emerged between ARMS and FEP patients. BPRS-EC was significantly correlated with lower intelligence (r=-.27; p=.008), reduced level of functioning (r=-.44; p<.001), and with smoking behavior (r=.22; p=.019).CONCLUSIONS: ARMS and FEP patients in our sample had significantly higher BPRS-EC scores compared to HC. This may constitute a correlate of an agitated-aggressive syndrome and an increased risk for aggression and suicidality.

KW - Adolescent

KW - Adult

KW - Aggression

KW - Brief Psychiatric Rating Scale

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Mental Disorders

KW - Middle Aged

KW - Multivariate Analysis

KW - Prodromal Symptoms

KW - Psychomotor Agitation

KW - Psychotic Disorders

KW - Risk

KW - Suicide

KW - Syndrome

KW - Young Adult

U2 - 10.1016/j.schres.2014.06.014

DO - 10.1016/j.schres.2014.06.014

M3 - SCORING: Journal article

C2 - 24996505

VL - 157

SP - 26

EP - 32

JO - SCHIZOPHR RES

JF - SCHIZOPHR RES

SN - 0920-9964

IS - 1-3

ER -