Evaluation of cartilage specific matrix synthesis of human articular chondrocytes after extended propagation on microcarriers by image analysis.
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Evaluation of cartilage specific matrix synthesis of human articular chondrocytes after extended propagation on microcarriers by image analysis. / Goepfert, Christiane; Lutz, Vivien; Lünse, Svenja; Kittel, Sabrina; Wiegandt, Katharina; Kammal, Michael; Püschel, Klaus; Pörtner, Ralf.
In: INT J ARTIF ORGANS, Vol. 33, No. 4, 4, 2010, p. 204-218.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Evaluation of cartilage specific matrix synthesis of human articular chondrocytes after extended propagation on microcarriers by image analysis.
AU - Goepfert, Christiane
AU - Lutz, Vivien
AU - Lünse, Svenja
AU - Kittel, Sabrina
AU - Wiegandt, Katharina
AU - Kammal, Michael
AU - Püschel, Klaus
AU - Pörtner, Ralf
PY - 2010
Y1 - 2010
N2 - Cell-based technologies for the repair of cartilage defects usually rely on the expansion of low numbers of chondrocytes isolated from biopsies of healthy cartilage. Proliferating chondrocytes are known to undergo dedifferentiation characterized by downregulation of collagen type II and proteoglycan production, and by upregulation of collagen type I synthesis. Re-expression of cartilage specific matrix components by expanded chondrocytes is therefore critical for successful cartilage repair.
AB - Cell-based technologies for the repair of cartilage defects usually rely on the expansion of low numbers of chondrocytes isolated from biopsies of healthy cartilage. Proliferating chondrocytes are known to undergo dedifferentiation characterized by downregulation of collagen type II and proteoglycan production, and by upregulation of collagen type I synthesis. Re-expression of cartilage specific matrix components by expanded chondrocytes is therefore critical for successful cartilage repair.
KW - Humans
KW - Transforming Growth Factor beta pharmacology
KW - Image Processing, Computer-Assisted
KW - Cell Differentiation physiology
KW - Tissue Engineering methods
KW - Insulin-Like Growth Factor I pharmacology
KW - Bone Morphogenetic Protein 7 pharmacology
KW - Cartilage, Articular cytology
KW - Chondrocytes metabolism
KW - Collagen drug effects
KW - Collagen Type II metabolism
KW - Humans
KW - Transforming Growth Factor beta pharmacology
KW - Image Processing, Computer-Assisted
KW - Cell Differentiation physiology
KW - Tissue Engineering methods
KW - Insulin-Like Growth Factor I pharmacology
KW - Bone Morphogenetic Protein 7 pharmacology
KW - Cartilage, Articular cytology
KW - Chondrocytes metabolism
KW - Collagen drug effects
KW - Collagen Type II metabolism
M3 - SCORING: Zeitschriftenaufsatz
VL - 33
SP - 204
EP - 218
JO - INT J ARTIF ORGANS
JF - INT J ARTIF ORGANS
SN - 0391-3988
IS - 4
M1 - 4
ER -