European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria

TY - JOUR

T1 - European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria

AU - Biancari, Fausto

AU - Mariscalco, Giovanni

AU - Yusuff, Hakeem

AU - Tsang, Geoffrey

AU - Luthra, Suvitesh

AU - Onorati, Francesco

AU - Francica, Alessandra

AU - Rossetti, Cecilia

AU - Perrotti, Andrea

AU - Chocron, Sidney

AU - Fiore, Antonio

AU - Folliguet, Thierry

AU - Pettinari, Matteo

AU - Dell'Aquila, Angelo M

AU - Demal, Till

AU - Conradi, Lenard

AU - Detter, Christian

AU - Pol, Marek

AU - Ivak, Peter

AU - Schlosser, Filip

AU - Forlani, Stefano

AU - Chetty, Govind

AU - Harky, Amer

AU - Kuduvalli, Manoj

AU - Field, Mark

AU - Vendramin, Igor

AU - Livi, Ugolino

AU - Rinaldi, Mauro

AU - Ferrante, Luisa

AU - Etz, Christian

AU - Noack, Thilo

AU - Mastrobuoni, Stefano

AU - De Kerchove, Laurent

AU - Jormalainen, Mikko

AU - Laga, Steven

AU - Meuris, Bart

AU - Schepens, Marc

AU - El Dean, Zein

AU - Vento, Antti

AU - Raivio, Peter

AU - Borger, Michael

AU - Juvonen, Tatu

PY - 2021/6/10

Y1 - 2021/6/10

N2 - BACKGROUND: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.METHODS: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient's comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.DISCUSSION: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04831073 .

AB - BACKGROUND: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.METHODS: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient's comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.DISCUSSION: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04831073 .

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aneurysm, Dissecting/mortality

KW - Aortic Aneurysm/mortality

KW - Clinical Protocols

KW - Comorbidity

KW - Europe

KW - Female

KW - Hospital Mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Postoperative Complications/epidemiology

KW - Prognosis

KW - Registries

KW - Reoperation/statistics & numerical data

KW - Research Design

KW - Retrospective Studies

KW - Risk Factors

KW - Vascular Grafting/instrumentation

U2 - 10.1186/s13019-021-01536-5

DO - 10.1186/s13019-021-01536-5

M3 - SCORING: Journal article

C2 - 34112230

VL - 16

JO - J CARDIOTHORAC SURG

JF - J CARDIOTHORAC SURG

SN - 1749-8090

IS - 1

M1 - 171

ER -