European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria
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European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria. / Biancari, Fausto; Mariscalco, Giovanni; Yusuff, Hakeem; Tsang, Geoffrey; Luthra, Suvitesh; Onorati, Francesco; Francica, Alessandra; Rossetti, Cecilia; Perrotti, Andrea; Chocron, Sidney; Fiore, Antonio; Folliguet, Thierry; Pettinari, Matteo; Dell'Aquila, Angelo M; Demal, Till; Conradi, Lenard; Detter, Christian; Pol, Marek; Ivak, Peter; Schlosser, Filip; Forlani, Stefano; Chetty, Govind; Harky, Amer; Kuduvalli, Manoj; Field, Mark; Vendramin, Igor; Livi, Ugolino; Rinaldi, Mauro; Ferrante, Luisa; Etz, Christian; Noack, Thilo; Mastrobuoni, Stefano; De Kerchove, Laurent; Jormalainen, Mikko; Laga, Steven; Meuris, Bart; Schepens, Marc; El Dean, Zein; Vento, Antti; Raivio, Peter; Borger, Michael; Juvonen, Tatu.
in: J CARDIOTHORAC SURG, Jahrgang 16, Nr. 1, 171, 10.06.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria
AU - Biancari, Fausto
AU - Mariscalco, Giovanni
AU - Yusuff, Hakeem
AU - Tsang, Geoffrey
AU - Luthra, Suvitesh
AU - Onorati, Francesco
AU - Francica, Alessandra
AU - Rossetti, Cecilia
AU - Perrotti, Andrea
AU - Chocron, Sidney
AU - Fiore, Antonio
AU - Folliguet, Thierry
AU - Pettinari, Matteo
AU - Dell'Aquila, Angelo M
AU - Demal, Till
AU - Conradi, Lenard
AU - Detter, Christian
AU - Pol, Marek
AU - Ivak, Peter
AU - Schlosser, Filip
AU - Forlani, Stefano
AU - Chetty, Govind
AU - Harky, Amer
AU - Kuduvalli, Manoj
AU - Field, Mark
AU - Vendramin, Igor
AU - Livi, Ugolino
AU - Rinaldi, Mauro
AU - Ferrante, Luisa
AU - Etz, Christian
AU - Noack, Thilo
AU - Mastrobuoni, Stefano
AU - De Kerchove, Laurent
AU - Jormalainen, Mikko
AU - Laga, Steven
AU - Meuris, Bart
AU - Schepens, Marc
AU - El Dean, Zein
AU - Vento, Antti
AU - Raivio, Peter
AU - Borger, Michael
AU - Juvonen, Tatu
PY - 2021/6/10
Y1 - 2021/6/10
N2 - BACKGROUND: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.METHODS: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient's comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.DISCUSSION: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04831073 .
AB - BACKGROUND: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.METHODS: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient's comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.DISCUSSION: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04831073 .
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aneurysm, Dissecting/mortality
KW - Aortic Aneurysm/mortality
KW - Clinical Protocols
KW - Comorbidity
KW - Europe
KW - Female
KW - Hospital Mortality
KW - Humans
KW - Male
KW - Middle Aged
KW - Postoperative Complications/epidemiology
KW - Prognosis
KW - Registries
KW - Reoperation/statistics & numerical data
KW - Research Design
KW - Retrospective Studies
KW - Risk Factors
KW - Vascular Grafting/instrumentation
U2 - 10.1186/s13019-021-01536-5
DO - 10.1186/s13019-021-01536-5
M3 - SCORING: Journal article
C2 - 34112230
VL - 16
JO - J CARDIOTHORAC SURG
JF - J CARDIOTHORAC SURG
SN - 1749-8090
IS - 1
M1 - 171
ER -