Estrogen synthesis in the hippocampus.
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Estrogen synthesis in the hippocampus. / Fester, Lars; Prange-Kiel, Janine; Jarry, Hubertus; Rune, Gabriele M.
In: CELL TISSUE RES, Vol. 345, No. 3, 3, 2011, p. 285-294.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Estrogen synthesis in the hippocampus.
AU - Fester, Lars
AU - Prange-Kiel, Janine
AU - Jarry, Hubertus
AU - Rune, Gabriele M.
PY - 2011
Y1 - 2011
N2 - Estradiol plays essential roles in the modulation of synaptic plasticity and neuroprotection in males as well as in females, as has been shown particularly in the hippocampus. Although it has long been known that aromatase, the final enzyme in estrogen synthesis, is expressed in the hippocampus, a new paradigm emerged when it was shown that estradiol is actually synthesized de novo in this part of the brain. Increasing evidence indicates that hippocampus-derived estradiol plays a role in synaptic plasticity and neuroptrotection, rather than estradiol originating from the gonads. In recent years, a number of in vivo and in vitro studies have shown that hippocampus-derived estradiol substantially contributes to hippocampal function, in particular to structural synaptic plasticity.
AB - Estradiol plays essential roles in the modulation of synaptic plasticity and neuroprotection in males as well as in females, as has been shown particularly in the hippocampus. Although it has long been known that aromatase, the final enzyme in estrogen synthesis, is expressed in the hippocampus, a new paradigm emerged when it was shown that estradiol is actually synthesized de novo in this part of the brain. Increasing evidence indicates that hippocampus-derived estradiol plays a role in synaptic plasticity and neuroptrotection, rather than estradiol originating from the gonads. In recent years, a number of in vivo and in vitro studies have shown that hippocampus-derived estradiol substantially contributes to hippocampal function, in particular to structural synaptic plasticity.
KW - Animals
KW - Humans
KW - Aromatase/metabolism
KW - Estrogens/biosynthesis
KW - Hippocampus/cytology/enzymology/metabolism
KW - Neurons/cytology/metabolism
KW - Animals
KW - Humans
KW - Aromatase/metabolism
KW - Estrogens/biosynthesis
KW - Hippocampus/cytology/enzymology/metabolism
KW - Neurons/cytology/metabolism
M3 - SCORING: Journal article
VL - 345
SP - 285
EP - 294
JO - CELL TISSUE RES
JF - CELL TISSUE RES
SN - 0302-766X
IS - 3
M1 - 3
ER -