Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function

Hanna Niehues; Joost Schalkwijk; Ivonne M J J van Vlijmen-Willems; Diana Rodijk-Olthuis; Michelle M van Rossum; Ewa Wladykowski; Johanna M Brandner; Ellen H J van den Bogaard; Patrick L J M Zeeuwen

doi:10.1016/j.jaci.2016.09.016

Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function

Hanna Niehues
Joost Schalkwijk
Ivonne M J J van Vlijmen-Willems
Diana Rodijk-Olthuis
Michelle M van Rossum
Ewa Wladykowski
Johanna M Brandner
Ellen H J van den Bogaard
Patrick L J M Zeeuwen

Related Research units

Department of Dermatology and Venereology

Abstract

We investigated differentiation and barrier properties of epidermal equivalents derived from ichthyosis vulgaris keratinocytes that were homozygous for FLG null mutations. We found no effect on penetration of tracer molecules, compared with filaggrin proficient keratinocytes.

Bibliographical data

Original language	English
ISSN	0091-6749
DOIs	https://doi.org/10.1016/j.jaci.2016.09.016
Publication status	Published - 06.2017

Comment Deanary

Letter

PubMed	27742393