Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function

Hanna Niehues; Joost Schalkwijk; Ivonne M J J van Vlijmen-Willems; Diana Rodijk-Olthuis; Michelle M van Rossum; Ewa Wladykowski; Johanna M Brandner; Ellen H J van den Bogaard; Patrick L J M Zeeuwen

doi:10.1016/j.jaci.2016.09.016

Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function

Hanna Niehues
Joost Schalkwijk
Ivonne M J J van Vlijmen-Willems
Diana Rodijk-Olthuis
Michelle M van Rossum
Ewa Wladykowski
Johanna M Brandner
Ellen H J van den Bogaard
Patrick L J M Zeeuwen

Beteiligte Einrichtungen

Klinik und Poliklinik für Dermatologie und Venerologie

Abstract

We investigated differentiation and barrier properties of epidermal equivalents derived from ichthyosis vulgaris keratinocytes that were homozygous for FLG null mutations. We found no effect on penetration of tracer molecules, compared with filaggrin proficient keratinocytes.

Bibliografische Daten

Originalsprache	Englisch
ISSN	0091-6749
DOIs	https://doi.org/10.1016/j.jaci.2016.09.016
Status	Veröffentlicht - 06.2017

PubMed	27742393