Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.
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Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. / Streeck, Hendrik; Jessen, Heiko; Kuecherer, Claudia; Li, Bin; Jessen, Arne B; Dupke, Stephan; Baumgarten, Axel; Stahmer, Ingrid; van Lunzen, Jan; Altfeld, Marcus; Walker, Bruce D; Allen, Todd M.
In: AIDS, Vol. 23, No. 2, 2, 2009, p. 259-262.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.
AU - Streeck, Hendrik
AU - Jessen, Heiko
AU - Kuecherer, Claudia
AU - Li, Bin
AU - Jessen, Arne B
AU - Dupke, Stephan
AU - Baumgarten, Axel
AU - Stahmer, Ingrid
AU - van Lunzen, Jan
AU - Altfeld, Marcus
AU - Walker, Bruce D
AU - Allen, Todd M
PY - 2009
Y1 - 2009
N2 - The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.
AB - The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.
KW - Humans
KW - Germany epidemiology
KW - Follow-Up Studies
KW - Antiretroviral Therapy, Highly Active
KW - CD4 Lymphocyte Count
KW - Genetic Predisposition to Disease
KW - HIV Infections genetics
KW - HIV-1 isolation
KW - purification
KW - Histocompatibility Testing
KW - Viral Load
KW - Humans
KW - Germany epidemiology
KW - Follow-Up Studies
KW - Antiretroviral Therapy, Highly Active
KW - CD4 Lymphocyte Count
KW - Genetic Predisposition to Disease
KW - HIV Infections genetics
KW - HIV-1 isolation
KW - purification
KW - Histocompatibility Testing
KW - Viral Load
M3 - SCORING: Zeitschriftenaufsatz
VL - 23
SP - 259
EP - 262
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 2
M1 - 2
ER -