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Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.

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Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. / Streeck, Hendrik; Jessen, Heiko; Kuecherer, Claudia; Li, Bin; Jessen, Arne B; Dupke, Stephan; Baumgarten, Axel; Stahmer, Ingrid; van Lunzen, Jan; Altfeld, Marcus; Walker, Bruce D; Allen, Todd M.

in: AIDS, Jahrgang 23, Nr. 2, 2, 2009, S. 259-262.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Streeck, H, Jessen, H, Kuecherer, C, Li, B, Jessen, AB, Dupke, S, Baumgarten, A, Stahmer, I, van Lunzen, J, Altfeld, M, Walker, BD & Allen, TM 2009, 'Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.', AIDS, Jg. 23, Nr. 2, 2, S. 259-262. <http://www.ncbi.nlm.nih.gov/pubmed/19098497?dopt=Citation>

APA

Streeck, H., Jessen, H., Kuecherer, C., Li, B., Jessen, A. B., Dupke, S., Baumgarten, A., Stahmer, I., van Lunzen, J., Altfeld, M., Walker, B. D., & Allen, T. M. (2009). Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. AIDS, 23(2), 259-262. [2]. http://www.ncbi.nlm.nih.gov/pubmed/19098497?dopt=Citation

Vancouver

Streeck H, Jessen H, Kuecherer C, Li B, Jessen AB, Dupke S et al. Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. AIDS. 2009;23(2):259-262. 2.

Bibtex

@article{b208d0d92eee4c21a636d93ff9b4519e,
title = "Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.",
abstract = "The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.",
keywords = "Humans, Germany epidemiology, Follow-Up Studies, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Genetic Predisposition to Disease, HIV Infections genetics, HIV-1 isolation, purification, Histocompatibility Testing, Viral Load, Humans, Germany epidemiology, Follow-Up Studies, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Genetic Predisposition to Disease, HIV Infections genetics, HIV-1 isolation, purification, Histocompatibility Testing, Viral Load",
author = "Hendrik Streeck and Heiko Jessen and Claudia Kuecherer and Bin Li and Jessen, {Arne B} and Stephan Dupke and Axel Baumgarten and Ingrid Stahmer and {van Lunzen}, Jan and Marcus Altfeld and Walker, {Bruce D} and Allen, {Todd M}",
year = "2009",
language = "Deutsch",
volume = "23",
pages = "259--262",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.

AU - Streeck, Hendrik

AU - Jessen, Heiko

AU - Kuecherer, Claudia

AU - Li, Bin

AU - Jessen, Arne B

AU - Dupke, Stephan

AU - Baumgarten, Axel

AU - Stahmer, Ingrid

AU - van Lunzen, Jan

AU - Altfeld, Marcus

AU - Walker, Bruce D

AU - Allen, Todd M

PY - 2009

Y1 - 2009

N2 - The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.

AB - The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.

KW - Humans

KW - Germany epidemiology

KW - Follow-Up Studies

KW - Antiretroviral Therapy, Highly Active

KW - CD4 Lymphocyte Count

KW - Genetic Predisposition to Disease

KW - HIV Infections genetics

KW - HIV-1 isolation

KW - purification

KW - Histocompatibility Testing

KW - Viral Load

KW - Humans

KW - Germany epidemiology

KW - Follow-Up Studies

KW - Antiretroviral Therapy, Highly Active

KW - CD4 Lymphocyte Count

KW - Genetic Predisposition to Disease

KW - HIV Infections genetics

KW - HIV-1 isolation

KW - purification

KW - Histocompatibility Testing

KW - Viral Load

M3 - SCORING: Zeitschriftenaufsatz

VL - 23

SP - 259

EP - 262

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 2

M1 - 2

ER -