Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury
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Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. / Laywell, E D; Dörries, U; Bartsch, U; Faissner, A; Schachner, M; Steindler, D A.
In: P NATL ACAD SCI USA, Vol. 89, No. 7, 01.04.1992, p. 2634-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury
AU - Laywell, E D
AU - Dörries, U
AU - Bartsch, U
AU - Faissner, A
AU - Schachner, M
AU - Steindler, D A
PY - 1992/4/1
Y1 - 1992/4/1
N2 - Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.
AB - Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.
KW - Age Factors
KW - Animals
KW - Brain Injuries
KW - Cell Adhesion Molecules, Neuronal
KW - Cerebellar Cortex
KW - Cerebral Cortex
KW - Extracellular Matrix Proteins
KW - Gene Expression
KW - Glial Fibrillary Acidic Protein
KW - Immunoenzyme Techniques
KW - Mice
KW - Mice, Inbred Strains
KW - Nucleic Acid Hybridization
KW - RNA, Messenger
KW - Tenascin
KW - Journal Article
KW - Research Support, U.S. Gov't, Non-P.H.S.
KW - Research Support, U.S. Gov't, P.H.S.
M3 - SCORING: Journal article
C2 - 1372985
VL - 89
SP - 2634
EP - 2638
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 7
ER -