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Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury

Standard

Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. / Laywell, E D; Dörries, U; Bartsch, U; Faissner, A; Schachner, M; Steindler, D A.

in: P NATL ACAD SCI USA, Jahrgang 89, Nr. 7, 01.04.1992, S. 2634-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Laywell, ED, Dörries, U, Bartsch, U, Faissner, A, Schachner, M & Steindler, DA 1992, 'Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury', P NATL ACAD SCI USA, Jg. 89, Nr. 7, S. 2634-8.

APA

Laywell, E. D., Dörries, U., Bartsch, U., Faissner, A., Schachner, M., & Steindler, D. A. (1992). Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. P NATL ACAD SCI USA, 89(7), 2634-8.

Vancouver

Laywell ED, Dörries U, Bartsch U, Faissner A, Schachner M, Steindler DA. Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury. P NATL ACAD SCI USA. 1992 Apr 1;89(7):2634-8.

Bibtex

@article{6405f2ae33bb4c8a8de07b70729d2163,
title = "Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury",
abstract = "Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.",
keywords = "Age Factors, Animals, Brain Injuries, Cell Adhesion Molecules, Neuronal, Cerebellar Cortex, Cerebral Cortex, Extracellular Matrix Proteins, Gene Expression, Glial Fibrillary Acidic Protein, Immunoenzyme Techniques, Mice, Mice, Inbred Strains, Nucleic Acid Hybridization, RNA, Messenger, Tenascin, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.",
author = "Laywell, {E D} and U D{\"o}rries and U Bartsch and A Faissner and M Schachner and Steindler, {D A}",
year = "1992",
month = apr,
day = "1",
language = "English",
volume = "89",
pages = "2634--8",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "7",

}

RIS

TY - JOUR

T1 - Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury

AU - Laywell, E D

AU - Dörries, U

AU - Bartsch, U

AU - Faissner, A

AU - Schachner, M

AU - Steindler, D A

PY - 1992/4/1

Y1 - 1992/4/1

N2 - Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.

AB - Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.

KW - Age Factors

KW - Animals

KW - Brain Injuries

KW - Cell Adhesion Molecules, Neuronal

KW - Cerebellar Cortex

KW - Cerebral Cortex

KW - Extracellular Matrix Proteins

KW - Gene Expression

KW - Glial Fibrillary Acidic Protein

KW - Immunoenzyme Techniques

KW - Mice

KW - Mice, Inbred Strains

KW - Nucleic Acid Hybridization

KW - RNA, Messenger

KW - Tenascin

KW - Journal Article

KW - Research Support, U.S. Gov't, Non-P.H.S.

KW - Research Support, U.S. Gov't, P.H.S.

M3 - SCORING: Journal article

C2 - 1372985

VL - 89

SP - 2634

EP - 2638

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 7

ER -