Engineering Cardiac Muscle Tissue
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Engineering Cardiac Muscle Tissue : A Maturating Field of Research. / Weinberger, Florian; Mannhardt, Ingra; Eschenhagen, Thomas.
In: CIRC RES, Vol. 120, No. 9, 28.04.2017, p. 1487-1500.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Engineering Cardiac Muscle Tissue
T2 - A Maturating Field of Research
AU - Weinberger, Florian
AU - Mannhardt, Ingra
AU - Eschenhagen, Thomas
N1 - © 2017 American Heart Association, Inc.
PY - 2017/4/28
Y1 - 2017/4/28
N2 - Twenty years after the initial description of a tissue engineered construct, 3-dimensional human cardiac tissues of different kinds are now generated routinely in many laboratories. Advances in stem cell biology and engineering allow for the generation of constructs that come close to recapitulating the complex structure of heart muscle and might, therefore, be amenable to industrial (eg, drug screening) and clinical (eg, cardiac repair) applications. Whether the more physiological structure of 3-dimensional constructs provides a relevant advantage over standard 2-dimensional cell culture has yet to be shown in head-to-head-comparisons. The present article gives an overview on current strategies of cardiac tissue engineering with a focus on different hydrogel methods and discusses perspectives and challenges for necessary steps toward the real-life application of cardiac tissue engineering for disease modeling, drug development, and cardiac repair.
AB - Twenty years after the initial description of a tissue engineered construct, 3-dimensional human cardiac tissues of different kinds are now generated routinely in many laboratories. Advances in stem cell biology and engineering allow for the generation of constructs that come close to recapitulating the complex structure of heart muscle and might, therefore, be amenable to industrial (eg, drug screening) and clinical (eg, cardiac repair) applications. Whether the more physiological structure of 3-dimensional constructs provides a relevant advantage over standard 2-dimensional cell culture has yet to be shown in head-to-head-comparisons. The present article gives an overview on current strategies of cardiac tissue engineering with a focus on different hydrogel methods and discusses perspectives and challenges for necessary steps toward the real-life application of cardiac tissue engineering for disease modeling, drug development, and cardiac repair.
KW - Animals
KW - Cardiology
KW - Cardiovascular Agents
KW - Cell Culture Techniques
KW - Cells, Cultured
KW - Disease Models, Animal
KW - Drug Discovery
KW - Drug Evaluation, Preclinical
KW - Heart Diseases
KW - Humans
KW - Myocardium
KW - Myocytes, Cardiac
KW - Phenotype
KW - Recovery of Function
KW - Regeneration
KW - Regenerative Medicine
KW - Stem Cell Transplantation
KW - Tissue Engineering
KW - Tissue Scaffolds
KW - Journal Article
KW - Review
U2 - 10.1161/CIRCRESAHA.117.310738
DO - 10.1161/CIRCRESAHA.117.310738
M3 - SCORING: Review article
C2 - 28450366
VL - 120
SP - 1487
EP - 1500
JO - CIRC RES
JF - CIRC RES
SN - 0009-7330
IS - 9
ER -