Engineering Cardiac Muscle Tissue: A Maturating Field of Research

Florian Weinberger; Ingra Mannhardt; Thomas Eschenhagen

doi:10.1161/CIRCRESAHA.117.310738

Engineering Cardiac Muscle Tissue

Standard

Engineering Cardiac Muscle Tissue : A Maturating Field of Research. / Weinberger, Florian; Mannhardt, Ingra; Eschenhagen, Thomas.

in: CIRC RES, Jahrgang 120, Nr. 9, 28.04.2017, S. 1487-1500.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Weinberger, F, Mannhardt, I & Eschenhagen, T 2017, 'Engineering Cardiac Muscle Tissue: A Maturating Field of Research', CIRC RES, Jg. 120, Nr. 9, S. 1487-1500. https://doi.org/10.1161/CIRCRESAHA.117.310738

APA

Weinberger, F., Mannhardt, I., & Eschenhagen, T. (2017). Engineering Cardiac Muscle Tissue: A Maturating Field of Research. CIRC RES, 120(9), 1487-1500. https://doi.org/10.1161/CIRCRESAHA.117.310738

Vancouver

Weinberger F, Mannhardt I, Eschenhagen T. Engineering Cardiac Muscle Tissue: A Maturating Field of Research. CIRC RES. 2017 Apr 28;120(9):1487-1500. https://doi.org/10.1161/CIRCRESAHA.117.310738

Bibtex

@article{769fc8446e5242c198d9da64f8fe9677,

title = "Engineering Cardiac Muscle Tissue: A Maturating Field of Research",

abstract = "Twenty years after the initial description of a tissue engineered construct, 3-dimensional human cardiac tissues of different kinds are now generated routinely in many laboratories. Advances in stem cell biology and engineering allow for the generation of constructs that come close to recapitulating the complex structure of heart muscle and might, therefore, be amenable to industrial (eg, drug screening) and clinical (eg, cardiac repair) applications. Whether the more physiological structure of 3-dimensional constructs provides a relevant advantage over standard 2-dimensional cell culture has yet to be shown in head-to-head-comparisons. The present article gives an overview on current strategies of cardiac tissue engineering with a focus on different hydrogel methods and discusses perspectives and challenges for necessary steps toward the real-life application of cardiac tissue engineering for disease modeling, drug development, and cardiac repair.",

keywords = "Animals, Cardiology, Cardiovascular Agents, Cell Culture Techniques, Cells, Cultured, Disease Models, Animal, Drug Discovery, Drug Evaluation, Preclinical, Heart Diseases, Humans, Myocardium, Myocytes, Cardiac, Phenotype, Recovery of Function, Regeneration, Regenerative Medicine, Stem Cell Transplantation, Tissue Engineering, Tissue Scaffolds, Journal Article, Review",

author = "Florian Weinberger and Ingra Mannhardt and Thomas Eschenhagen",

note = "{\textcopyright} 2017 American Heart Association, Inc.",

year = "2017",

month = apr,

day = "28",

doi = "10.1161/CIRCRESAHA.117.310738",

language = "English",

volume = "120",

pages = "1487--1500",

journal = "CIRC RES",

issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

RIS

TY - JOUR

T1 - Engineering Cardiac Muscle Tissue

T2 - A Maturating Field of Research

AU - Weinberger, Florian

AU - Mannhardt, Ingra

AU - Eschenhagen, Thomas

PY - 2017/4/28

Y1 - 2017/4/28

N2 - Twenty years after the initial description of a tissue engineered construct, 3-dimensional human cardiac tissues of different kinds are now generated routinely in many laboratories. Advances in stem cell biology and engineering allow for the generation of constructs that come close to recapitulating the complex structure of heart muscle and might, therefore, be amenable to industrial (eg, drug screening) and clinical (eg, cardiac repair) applications. Whether the more physiological structure of 3-dimensional constructs provides a relevant advantage over standard 2-dimensional cell culture has yet to be shown in head-to-head-comparisons. The present article gives an overview on current strategies of cardiac tissue engineering with a focus on different hydrogel methods and discusses perspectives and challenges for necessary steps toward the real-life application of cardiac tissue engineering for disease modeling, drug development, and cardiac repair.

AB - Twenty years after the initial description of a tissue engineered construct, 3-dimensional human cardiac tissues of different kinds are now generated routinely in many laboratories. Advances in stem cell biology and engineering allow for the generation of constructs that come close to recapitulating the complex structure of heart muscle and might, therefore, be amenable to industrial (eg, drug screening) and clinical (eg, cardiac repair) applications. Whether the more physiological structure of 3-dimensional constructs provides a relevant advantage over standard 2-dimensional cell culture has yet to be shown in head-to-head-comparisons. The present article gives an overview on current strategies of cardiac tissue engineering with a focus on different hydrogel methods and discusses perspectives and challenges for necessary steps toward the real-life application of cardiac tissue engineering for disease modeling, drug development, and cardiac repair.

KW - Animals

KW - Cardiology

KW - Cardiovascular Agents

KW - Cell Culture Techniques

KW - Cells, Cultured

KW - Disease Models, Animal

KW - Drug Discovery

KW - Drug Evaluation, Preclinical

KW - Heart Diseases

KW - Humans

KW - Myocardium

KW - Myocytes, Cardiac

KW - Phenotype

KW - Recovery of Function

KW - Regeneration

KW - Regenerative Medicine

KW - Stem Cell Transplantation

KW - Tissue Engineering

KW - Tissue Scaffolds

KW - Journal Article

KW - Review

U2 - 10.1161/CIRCRESAHA.117.310738

DO - 10.1161/CIRCRESAHA.117.310738

M3 - SCORING: Review article

C2 - 28450366

VL - 120

SP - 1487

EP - 1500

JO - CIRC RES

JF - CIRC RES

SN - 0009-7330

IS - 9

ER -