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Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives

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Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives. / Hezel, Marcus; von Usslar, Kathrin; Kurzweg, Thiemo; Lörincz, Balazs B; Knecht, Rainald.

In: EUR ARCH OTO-RHINO-L, Vol. 273, No. 4, 04.2016, p. 837-44.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hezel, M, von Usslar, K, Kurzweg, T, Lörincz, BB & Knecht, R 2016, 'Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives', EUR ARCH OTO-RHINO-L, vol. 273, no. 4, pp. 837-44. https://doi.org/10.1007/s00405-014-3472-x

APA

Hezel, M., von Usslar, K., Kurzweg, T., Lörincz, B. B., & Knecht, R. (2016). Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives. EUR ARCH OTO-RHINO-L, 273(4), 837-44. https://doi.org/10.1007/s00405-014-3472-x

Vancouver

Hezel M, von Usslar K, Kurzweg T, Lörincz BB, Knecht R. Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives. EUR ARCH OTO-RHINO-L. 2016 Apr;273(4):837-44. https://doi.org/10.1007/s00405-014-3472-x

Bibtex

@article{52422c28a9954a48860d9432a1cb6259,
title = "Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives",
abstract = "This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.",
author = "Marcus Hezel and {von Usslar}, Kathrin and Thiemo Kurzweg and L{\"o}rincz, {Balazs B} and Rainald Knecht",
year = "2016",
month = apr,
doi = "10.1007/s00405-014-3472-x",
language = "English",
volume = "273",
pages = "837--44",
journal = "EUR ARCH OTO-RHINO-L",
issn = "0937-4477",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives

AU - Hezel, Marcus

AU - von Usslar, Kathrin

AU - Kurzweg, Thiemo

AU - Lörincz, Balazs B

AU - Knecht, Rainald

PY - 2016/4

Y1 - 2016/4

N2 - This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.

AB - This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.

U2 - 10.1007/s00405-014-3472-x

DO - 10.1007/s00405-014-3472-x

M3 - SCORING: Journal article

C2 - 25573834

VL - 273

SP - 837

EP - 844

JO - EUR ARCH OTO-RHINO-L

JF - EUR ARCH OTO-RHINO-L

SN - 0937-4477

IS - 4

ER -