Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives
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Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives. / Hezel, Marcus; von Usslar, Kathrin; Kurzweg, Thiemo; Lörincz, Balazs B; Knecht, Rainald.
in: EUR ARCH OTO-RHINO-L, Jahrgang 273, Nr. 4, 04.2016, S. 837-44.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives
AU - Hezel, Marcus
AU - von Usslar, Kathrin
AU - Kurzweg, Thiemo
AU - Lörincz, Balazs B
AU - Knecht, Rainald
PY - 2016/4
Y1 - 2016/4
N2 - This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.
AB - This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.
U2 - 10.1007/s00405-014-3472-x
DO - 10.1007/s00405-014-3472-x
M3 - SCORING: Journal article
C2 - 25573834
VL - 273
SP - 837
EP - 844
JO - EUR ARCH OTO-RHINO-L
JF - EUR ARCH OTO-RHINO-L
SN - 0937-4477
IS - 4
ER -