Endovascular Treatment for Acute Stroke in Cerebral Amyloid Angiopathy
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Endovascular Treatment for Acute Stroke in Cerebral Amyloid Angiopathy. / Weller, Johannes M; Enkirch, Simon Jonas; Bogs, Christopher; Braemswig, Tim Bastian; Deb-Chatterji, Milani; Keil, Fee; Kindler, Christine; Maywald, Sarah; Schirmer, Markus D; Stösser, Sebastian; Solymosi, Laszlo; Nolte, Christian H; Bode, Felix J; Petzold, Gabor C; German Stroke Registry – Endovascular Treatment (GSR – ET).
In: STROKE, Vol. 52, No. 10, 10.2021, p. e581-e585.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Endovascular Treatment for Acute Stroke in Cerebral Amyloid Angiopathy
AU - Weller, Johannes M
AU - Enkirch, Simon Jonas
AU - Bogs, Christopher
AU - Braemswig, Tim Bastian
AU - Deb-Chatterji, Milani
AU - Keil, Fee
AU - Kindler, Christine
AU - Maywald, Sarah
AU - Schirmer, Markus D
AU - Stösser, Sebastian
AU - Solymosi, Laszlo
AU - Nolte, Christian H
AU - Bode, Felix J
AU - Petzold, Gabor C
AU - German Stroke Registry – Endovascular Treatment (GSR – ET)
PY - 2021/10
Y1 - 2021/10
N2 - Background and Purpose: We aimed to compare outcome of endovascular thrombectomy in acute ischemic stroke in patients with and without cerebral amyloid angiopathy (CAA).Methods: We included patients with and without possible or probable CAA based on the modified Boston criteria from an observational multicenter cohort of patients with acute ischemic stroke and endovascular thrombectomy, the German Stroke Registry Endovascular Treatment trial. We analyzed baseline characteristics, procedural parameters, and functional outcome after 90 days.Results: Twenty-eight (17.3%) of 162 acute ischemic stroke patients were diagnosed with CAA based on iron-sensitive magnetic resonance imaging performed before endovascular thrombectomy. CAA patients were less likely to have a good 90-day outcome (14.3 versus 37.8%). National Institutes of Health Stroke Scale score (adjusted odds ratio, 0.88; P<0.001), successful recanalization (adjusted odds ratio 6.82; P=0.005), and CAA (adjusted odds ratio 0.28; P=0.049) were independent outcome predictors. Intravenous thrombolysis was associated with an increased rate of good outcome (36.3% versus 0%, P=0.031) in CAA.Conclusions: Endovascular thrombectomy with or without thrombolysis appears beneficial in acute ischemic stroke patients with possible or probable CAA, but is associated with a worse functional outcome.Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03356392.
AB - Background and Purpose: We aimed to compare outcome of endovascular thrombectomy in acute ischemic stroke in patients with and without cerebral amyloid angiopathy (CAA).Methods: We included patients with and without possible or probable CAA based on the modified Boston criteria from an observational multicenter cohort of patients with acute ischemic stroke and endovascular thrombectomy, the German Stroke Registry Endovascular Treatment trial. We analyzed baseline characteristics, procedural parameters, and functional outcome after 90 days.Results: Twenty-eight (17.3%) of 162 acute ischemic stroke patients were diagnosed with CAA based on iron-sensitive magnetic resonance imaging performed before endovascular thrombectomy. CAA patients were less likely to have a good 90-day outcome (14.3 versus 37.8%). National Institutes of Health Stroke Scale score (adjusted odds ratio, 0.88; P<0.001), successful recanalization (adjusted odds ratio 6.82; P=0.005), and CAA (adjusted odds ratio 0.28; P=0.049) were independent outcome predictors. Intravenous thrombolysis was associated with an increased rate of good outcome (36.3% versus 0%, P=0.031) in CAA.Conclusions: Endovascular thrombectomy with or without thrombolysis appears beneficial in acute ischemic stroke patients with possible or probable CAA, but is associated with a worse functional outcome.Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03356392.
U2 - 10.1161/STROKEAHA.120.033014
DO - 10.1161/STROKEAHA.120.033014
M3 - SCORING: Journal article
C2 - 34412512
VL - 52
SP - e581-e585
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 10
ER -