Endovascular Treatment for Acute Stroke in Cerebral Amyloid Angiopathy

TY - JOUR

T1 - Endovascular Treatment for Acute Stroke in Cerebral Amyloid Angiopathy

AU - Weller, Johannes M

AU - Enkirch, Simon Jonas

AU - Bogs, Christopher

AU - Braemswig, Tim Bastian

AU - Deb-Chatterji, Milani

AU - Keil, Fee

AU - Kindler, Christine

AU - Maywald, Sarah

AU - Schirmer, Markus D

AU - Stösser, Sebastian

AU - Solymosi, Laszlo

AU - Nolte, Christian H

AU - Bode, Felix J

AU - Petzold, Gabor C

AU - German Stroke Registry – Endovascular Treatment (GSR – ET)

PY - 2021/10

Y1 - 2021/10

N2 - Background and Purpose: We aimed to compare outcome of endovascular thrombectomy in acute ischemic stroke in patients with and without cerebral amyloid angiopathy (CAA).Methods: We included patients with and without possible or probable CAA based on the modified Boston criteria from an observational multicenter cohort of patients with acute ischemic stroke and endovascular thrombectomy, the German Stroke Registry Endovascular Treatment trial. We analyzed baseline characteristics, procedural parameters, and functional outcome after 90 days.Results: Twenty-eight (17.3%) of 162 acute ischemic stroke patients were diagnosed with CAA based on iron-sensitive magnetic resonance imaging performed before endovascular thrombectomy. CAA patients were less likely to have a good 90-day outcome (14.3 versus 37.8%). National Institutes of Health Stroke Scale score (adjusted odds ratio, 0.88; P<0.001), successful recanalization (adjusted odds ratio 6.82; P=0.005), and CAA (adjusted odds ratio 0.28; P=0.049) were independent outcome predictors. Intravenous thrombolysis was associated with an increased rate of good outcome (36.3% versus 0%, P=0.031) in CAA.Conclusions: Endovascular thrombectomy with or without thrombolysis appears beneficial in acute ischemic stroke patients with possible or probable CAA, but is associated with a worse functional outcome.Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03356392.

AB - Background and Purpose: We aimed to compare outcome of endovascular thrombectomy in acute ischemic stroke in patients with and without cerebral amyloid angiopathy (CAA).Methods: We included patients with and without possible or probable CAA based on the modified Boston criteria from an observational multicenter cohort of patients with acute ischemic stroke and endovascular thrombectomy, the German Stroke Registry Endovascular Treatment trial. We analyzed baseline characteristics, procedural parameters, and functional outcome after 90 days.Results: Twenty-eight (17.3%) of 162 acute ischemic stroke patients were diagnosed with CAA based on iron-sensitive magnetic resonance imaging performed before endovascular thrombectomy. CAA patients were less likely to have a good 90-day outcome (14.3 versus 37.8%). National Institutes of Health Stroke Scale score (adjusted odds ratio, 0.88; P<0.001), successful recanalization (adjusted odds ratio 6.82; P=0.005), and CAA (adjusted odds ratio 0.28; P=0.049) were independent outcome predictors. Intravenous thrombolysis was associated with an increased rate of good outcome (36.3% versus 0%, P=0.031) in CAA.Conclusions: Endovascular thrombectomy with or without thrombolysis appears beneficial in acute ischemic stroke patients with possible or probable CAA, but is associated with a worse functional outcome.Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03356392.

U2 - 10.1161/STROKEAHA.120.033014

DO - 10.1161/STROKEAHA.120.033014

M3 - SCORING: Journal article

C2 - 34412512

VL - 52

SP - e581-e585

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 10

ER -