Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.

S Ergün; Nerbil Kilic; J H Wurmbach; A Ebrahimnejad; M Fernando; S Sevinc; E Kilic; F Chalajour; W Fiedler; H Lauke; K Lamszus; P Hammerer; J Weil; H Herbst; J Folkman

Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.

Standard

Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. / Ergün, S; Kilic, Nerbil; Wurmbach, J H; Ebrahimnejad, A; Fernando, M; Sevinc, S; Kilic, E; Chalajour, F; Fiedler, W; Lauke, H; Lamszus, K; Hammerer, P; Weil, J; Herbst, H; Folkman, J.

In: ANGIOGENESIS, Vol. 4, No. 3, 3, 2001, p. 193-206.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ergün, S, Kilic, N, Wurmbach, JH, Ebrahimnejad, A, Fernando, M, Sevinc, S, Kilic, E, Chalajour, F, Fiedler, W, Lauke, H, Lamszus, K, Hammerer, P, Weil, J, Herbst, H & Folkman, J 2001, 'Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.', ANGIOGENESIS, vol. 4, no. 3, 3, pp. 193-206. <http://www.ncbi.nlm.nih.gov/pubmed/11911017?dopt=Citation>

APA

Ergün, S., Kilic, N., Wurmbach, J. H., Ebrahimnejad, A., Fernando, M., Sevinc, S., Kilic, E., Chalajour, F., Fiedler, W., Lauke, H., Lamszus, K., Hammerer, P., Weil, J., Herbst, H., & Folkman, J. (2001). Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. ANGIOGENESIS, 4(3), 193-206. [3]. http://www.ncbi.nlm.nih.gov/pubmed/11911017?dopt=Citation

Vancouver

Ergün S, Kilic N, Wurmbach JH, Ebrahimnejad A, Fernando M, Sevinc S et al. Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. ANGIOGENESIS. 2001;4(3):193-206. 3.

Bibtex

@article{f4c9f77cf7064b9eabe479ddf1be80f5,

title = "Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.",

abstract = "Endostatin decreased vascular endothelial growth factor (VEGF)-induced formation of endothelial tubes and microvessels sprouting from aortic rings and blocked their network. After cessation of treatment, the survival time of endostatin plus VEGF-treated tubes was approximately doubled in comparison to VEGF alone. Endostatin antibody blocked VEGF-induced endothelial tube formation and disrupted existing tubes. Endostatin immunostaining was localized between endothelium and basement membrane and in inter-endothelial junctions of new, but not of quiescent, blood vessels. In tumors grown in SCID mice, endostatin immunostaining was stronger accompanying blood vessel maturation and was significantly prominent in vessels of tumor marginal zone where angiogenesis is highly active. These data indicate a new antiangiogenic action of endostatin stabilizing and maturating endothelial tubes of newly formed blood vessels. Thus, strategies accelerating vascular stabilization and maturation could be promising in tumor therapy.",

author = "S Erg{\"u}n and Nerbil Kilic and Wurmbach, {J H} and A Ebrahimnejad and M Fernando and S Sevinc and E Kilic and F Chalajour and W Fiedler and H Lauke and K Lamszus and P Hammerer and J Weil and H Herbst and J Folkman",

year = "2001",

language = "Deutsch",

volume = "4",

pages = "193--206",

journal = "ANGIOGENESIS",

issn = "0969-6970",

publisher = "Springer Netherlands",

number = "3",

}

RIS

TY - JOUR

T1 - Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.

AU - Ergün, S

AU - Kilic, Nerbil

AU - Wurmbach, J H

AU - Ebrahimnejad, A

AU - Fernando, M

AU - Sevinc, S

AU - Kilic, E

AU - Chalajour, F

AU - Fiedler, W

AU - Lauke, H

AU - Lamszus, K

AU - Hammerer, P

AU - Weil, J

AU - Herbst, H

AU - Folkman, J

PY - 2001

Y1 - 2001

N2 - Endostatin decreased vascular endothelial growth factor (VEGF)-induced formation of endothelial tubes and microvessels sprouting from aortic rings and blocked their network. After cessation of treatment, the survival time of endostatin plus VEGF-treated tubes was approximately doubled in comparison to VEGF alone. Endostatin antibody blocked VEGF-induced endothelial tube formation and disrupted existing tubes. Endostatin immunostaining was localized between endothelium and basement membrane and in inter-endothelial junctions of new, but not of quiescent, blood vessels. In tumors grown in SCID mice, endostatin immunostaining was stronger accompanying blood vessel maturation and was significantly prominent in vessels of tumor marginal zone where angiogenesis is highly active. These data indicate a new antiangiogenic action of endostatin stabilizing and maturating endothelial tubes of newly formed blood vessels. Thus, strategies accelerating vascular stabilization and maturation could be promising in tumor therapy.

AB - Endostatin decreased vascular endothelial growth factor (VEGF)-induced formation of endothelial tubes and microvessels sprouting from aortic rings and blocked their network. After cessation of treatment, the survival time of endostatin plus VEGF-treated tubes was approximately doubled in comparison to VEGF alone. Endostatin antibody blocked VEGF-induced endothelial tube formation and disrupted existing tubes. Endostatin immunostaining was localized between endothelium and basement membrane and in inter-endothelial junctions of new, but not of quiescent, blood vessels. In tumors grown in SCID mice, endostatin immunostaining was stronger accompanying blood vessel maturation and was significantly prominent in vessels of tumor marginal zone where angiogenesis is highly active. These data indicate a new antiangiogenic action of endostatin stabilizing and maturating endothelial tubes of newly formed blood vessels. Thus, strategies accelerating vascular stabilization and maturation could be promising in tumor therapy.

M3 - SCORING: Zeitschriftenaufsatz

VL - 4

SP - 193

EP - 206

JO - ANGIOGENESIS

JF - ANGIOGENESIS

SN - 0969-6970

IS - 3

M1 - 3

ER -