Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.
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Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. / Ergün, S; Kilic, Nerbil; Wurmbach, J H; Ebrahimnejad, A; Fernando, M; Sevinc, S; Kilic, E; Chalajour, F; Fiedler, W; Lauke, H; Lamszus, K; Hammerer, P; Weil, J; Herbst, H; Folkman, J.
in: ANGIOGENESIS, Jahrgang 4, Nr. 3, 3, 2001, S. 193-206.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.
AU - Ergün, S
AU - Kilic, Nerbil
AU - Wurmbach, J H
AU - Ebrahimnejad, A
AU - Fernando, M
AU - Sevinc, S
AU - Kilic, E
AU - Chalajour, F
AU - Fiedler, W
AU - Lauke, H
AU - Lamszus, K
AU - Hammerer, P
AU - Weil, J
AU - Herbst, H
AU - Folkman, J
PY - 2001
Y1 - 2001
N2 - Endostatin decreased vascular endothelial growth factor (VEGF)-induced formation of endothelial tubes and microvessels sprouting from aortic rings and blocked their network. After cessation of treatment, the survival time of endostatin plus VEGF-treated tubes was approximately doubled in comparison to VEGF alone. Endostatin antibody blocked VEGF-induced endothelial tube formation and disrupted existing tubes. Endostatin immunostaining was localized between endothelium and basement membrane and in inter-endothelial junctions of new, but not of quiescent, blood vessels. In tumors grown in SCID mice, endostatin immunostaining was stronger accompanying blood vessel maturation and was significantly prominent in vessels of tumor marginal zone where angiogenesis is highly active. These data indicate a new antiangiogenic action of endostatin stabilizing and maturating endothelial tubes of newly formed blood vessels. Thus, strategies accelerating vascular stabilization and maturation could be promising in tumor therapy.
AB - Endostatin decreased vascular endothelial growth factor (VEGF)-induced formation of endothelial tubes and microvessels sprouting from aortic rings and blocked their network. After cessation of treatment, the survival time of endostatin plus VEGF-treated tubes was approximately doubled in comparison to VEGF alone. Endostatin antibody blocked VEGF-induced endothelial tube formation and disrupted existing tubes. Endostatin immunostaining was localized between endothelium and basement membrane and in inter-endothelial junctions of new, but not of quiescent, blood vessels. In tumors grown in SCID mice, endostatin immunostaining was stronger accompanying blood vessel maturation and was significantly prominent in vessels of tumor marginal zone where angiogenesis is highly active. These data indicate a new antiangiogenic action of endostatin stabilizing and maturating endothelial tubes of newly formed blood vessels. Thus, strategies accelerating vascular stabilization and maturation could be promising in tumor therapy.
M3 - SCORING: Zeitschriftenaufsatz
VL - 4
SP - 193
EP - 206
JO - ANGIOGENESIS
JF - ANGIOGENESIS
SN - 0969-6970
IS - 3
M1 - 3
ER -