Research ExplorerPublicationsEndocrine regulation of estrogen synthesis in the hippocampu...

Endocrine regulation of estrogen synthesis in the hippocampus?

Standard

Endocrine regulation of estrogen synthesis in the hippocampus? / Prange-Kiel, Janine; Schmutterer, Tobias; Fester, Lars; Zhou, Lepu; Imholz, Philipp; Brandt, Nicola; Vierk, Ricardo; Jarry, Hubertus; Rune, Gabriele M.

In: PROG HISTOCHEM CYTO, Vol. 48, No. 2, 01.08.2013, p. 49-64.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Prange-Kiel, J, Schmutterer, T, Fester, L, Zhou, L, Imholz, P, Brandt, N, Vierk, R, Jarry, H & Rune, GM 2013, 'Endocrine regulation of estrogen synthesis in the hippocampus?', PROG HISTOCHEM CYTO, vol. 48, no. 2, pp. 49-64. https://doi.org/10.1016/j.proghi.2013.07.002

APA

Prange-Kiel, J., Schmutterer, T., Fester, L., Zhou, L., Imholz, P., Brandt, N., Vierk, R., Jarry, H., & Rune, G. M. (2013). Endocrine regulation of estrogen synthesis in the hippocampus? PROG HISTOCHEM CYTO, 48(2), 49-64. https://doi.org/10.1016/j.proghi.2013.07.002

Vancouver

Prange-Kiel J, Schmutterer T, Fester L, Zhou L, Imholz P, Brandt N et al. Endocrine regulation of estrogen synthesis in the hippocampus? PROG HISTOCHEM CYTO. 2013 Aug 1;48(2):49-64. https://doi.org/10.1016/j.proghi.2013.07.002

Bibtex

@article{d1b92c50c642440786a1c96eac46b4df,
title = "Endocrine regulation of estrogen synthesis in the hippocampus?",
abstract = "Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.",
keywords = "Animals, Dendritic Spines, Dose-Response Relationship, Drug, Estradiol, Female, Gonadotropin-Releasing Hormone, Hippocampus, Immunohistochemistry, Male, Mice, Neurons, Rats, Receptors, LHRH, Reverse Transcriptase Polymerase Chain Reaction, Sex Factors, Synapses, Tissue Culture Techniques",
author = "Janine Prange-Kiel and Tobias Schmutterer and Lars Fester and Lepu Zhou and Philipp Imholz and Nicola Brandt and Ricardo Vierk and Hubertus Jarry and Rune, {Gabriele M}",
note = "Copyright {\textcopyright} 2013 Elsevier GmbH. All rights reserved.",
year = "2013",
month = aug,
day = "1",
doi = "10.1016/j.proghi.2013.07.002",
language = "English",
volume = "48",
pages = "49--64",
journal = "PROG HISTOCHEM CYTO",
issn = "0079-6336",
publisher = "Urban und Fischer Verlag Jena",
number = "2",

}

RIS

TY - JOUR

T1 - Endocrine regulation of estrogen synthesis in the hippocampus?

AU - Prange-Kiel, Janine

AU - Schmutterer, Tobias

AU - Fester, Lars

AU - Zhou, Lepu

AU - Imholz, Philipp

AU - Brandt, Nicola

AU - Vierk, Ricardo

AU - Jarry, Hubertus

AU - Rune, Gabriele M

N1 - Copyright © 2013 Elsevier GmbH. All rights reserved.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.

AB - Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.

KW - Animals

KW - Dendritic Spines

KW - Dose-Response Relationship, Drug

KW - Estradiol

KW - Female

KW - Gonadotropin-Releasing Hormone

KW - Hippocampus

KW - Immunohistochemistry

KW - Male

KW - Mice

KW - Neurons

KW - Rats

KW - Receptors, LHRH

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Sex Factors

KW - Synapses

KW - Tissue Culture Techniques

U2 - 10.1016/j.proghi.2013.07.002

DO - 10.1016/j.proghi.2013.07.002

M3 - SCORING: Journal article

C2 - 23906992

VL - 48

SP - 49

EP - 64

JO - PROG HISTOCHEM CYTO

JF - PROG HISTOCHEM CYTO

SN - 0079-6336

IS - 2

ER -