Endocrine regulation of estrogen synthesis in the hippocampus?
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Endocrine regulation of estrogen synthesis in the hippocampus? / Prange-Kiel, Janine; Schmutterer, Tobias; Fester, Lars; Zhou, Lepu; Imholz, Philipp; Brandt, Nicola; Vierk, Ricardo; Jarry, Hubertus; Rune, Gabriele M.
in: PROG HISTOCHEM CYTO, Jahrgang 48, Nr. 2, 01.08.2013, S. 49-64.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Endocrine regulation of estrogen synthesis in the hippocampus?
AU - Prange-Kiel, Janine
AU - Schmutterer, Tobias
AU - Fester, Lars
AU - Zhou, Lepu
AU - Imholz, Philipp
AU - Brandt, Nicola
AU - Vierk, Ricardo
AU - Jarry, Hubertus
AU - Rune, Gabriele M
N1 - Copyright © 2013 Elsevier GmbH. All rights reserved.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.
AB - Estradiol synthesis in the ovaries is regulated via feedback mechanisms mediated by gonadotrophin-releasing hormone (GnRH) and gonadotrophins, secreted by the hypothalamus and the pituitary, respectively. Estradiol synthesis also takes place in the hippocampus. In hippocampal slice cultures of female animals, GnRH regulates estradiol synthesis dose-dependently. Hence, both hippocampal and ovarian estradiol synthesis are synchronized by GnRH. Hippocampus-derived estradiol is essential to synapse stability and maintenance because it stabilizes the spine cytoskeleton of hippocampal neurons. Inhibition of hippocampal estradiol synthesis in mice, however, results in loss of spines and spine synapses in females, but not in males. Stereotaxic application of GnRH to the hippocampus of female rats confirms the regulatory role of GnRH on estradiol synthesis and synapse density in the female hippocampus in vivo. This regulatory role of GnRH necessarily results in estrus cyclicity of spine density in the hippocampus of females.
KW - Animals
KW - Dendritic Spines
KW - Dose-Response Relationship, Drug
KW - Estradiol
KW - Female
KW - Gonadotropin-Releasing Hormone
KW - Hippocampus
KW - Immunohistochemistry
KW - Male
KW - Mice
KW - Neurons
KW - Rats
KW - Receptors, LHRH
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Sex Factors
KW - Synapses
KW - Tissue Culture Techniques
U2 - 10.1016/j.proghi.2013.07.002
DO - 10.1016/j.proghi.2013.07.002
M3 - SCORING: Journal article
C2 - 23906992
VL - 48
SP - 49
EP - 64
JO - PROG HISTOCHEM CYTO
JF - PROG HISTOCHEM CYTO
SN - 0079-6336
IS - 2
ER -