Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression.

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Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression. / Gold, Stefan; Krüger, Schulamith; Ziegler, Kristin; Krieger, Thorsten; Schulz, Karl-Heinz; Otte, Christian; Heesen, Christoph.

In: J NEUROL NEUROSUR PS, Vol. 82, No. 7, 7, 2011, p. 814-818.

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@article{32bb1823df5f4b22b17c1f345615008f,
title = "Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression.",
abstract = "Depression and fatigue are among the most common symptoms of multiple sclerosis (MS). These symptoms frequently co-occur and partially overlap in MS but their underlying biological substrates are unclear. In this study, the relative role of cytokines and hypothalamic-pituitary-adrenal (HPA) axis activity in depression and fatigue were examined in patients with relapsing-remitting MS (RRMS).",
keywords = "Adult, Humans, Female, Middle Aged, Questionnaires, Young Adult, Socioeconomic Factors, Regression Analysis, Flow Cytometry, Diagnostic and Statistical Manual of Mental Disorders, T-Lymphocytes/metabolism, Interferon-gamma/metabolism, Tumor Necrosis Factor-alpha/metabolism, Lymphocyte Count, Hypothalamo-Hypophyseal System/physiopathology, Cytokines/metabolism, Depressive Disorder, Major/*etiology/*physiopathology, Endocrine Glands/*physiopathology, Fatigue/*etiology, Hydrocortisone/blood, Immune System/*physiopathology, Multiple Sclerosis, Relapsing-Remitting/*complications/*physiopathology/psychology, Adult, Humans, Female, Middle Aged, Questionnaires, Young Adult, Socioeconomic Factors, Regression Analysis, Flow Cytometry, Diagnostic and Statistical Manual of Mental Disorders, T-Lymphocytes/metabolism, Interferon-gamma/metabolism, Tumor Necrosis Factor-alpha/metabolism, Lymphocyte Count, Hypothalamo-Hypophyseal System/physiopathology, Cytokines/metabolism, Depressive Disorder, Major/*etiology/*physiopathology, Endocrine Glands/*physiopathology, Fatigue/*etiology, Hydrocortisone/blood, Immune System/*physiopathology, Multiple Sclerosis, Relapsing-Remitting/*complications/*physiopathology/psychology",
author = "Stefan Gold and Schulamith Kr{\"u}ger and Kristin Ziegler and Thorsten Krieger and Karl-Heinz Schulz and Christian Otte and Christoph Heesen",
year = "2011",
language = "English",
volume = "82",
pages = "814--818",
journal = "J NEUROL NEUROSUR PS",
issn = "0022-3050",
publisher = "BMJ PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression.

AU - Gold, Stefan

AU - Krüger, Schulamith

AU - Ziegler, Kristin

AU - Krieger, Thorsten

AU - Schulz, Karl-Heinz

AU - Otte, Christian

AU - Heesen, Christoph

PY - 2011

Y1 - 2011

N2 - Depression and fatigue are among the most common symptoms of multiple sclerosis (MS). These symptoms frequently co-occur and partially overlap in MS but their underlying biological substrates are unclear. In this study, the relative role of cytokines and hypothalamic-pituitary-adrenal (HPA) axis activity in depression and fatigue were examined in patients with relapsing-remitting MS (RRMS).

AB - Depression and fatigue are among the most common symptoms of multiple sclerosis (MS). These symptoms frequently co-occur and partially overlap in MS but their underlying biological substrates are unclear. In this study, the relative role of cytokines and hypothalamic-pituitary-adrenal (HPA) axis activity in depression and fatigue were examined in patients with relapsing-remitting MS (RRMS).

KW - Adult

KW - Humans

KW - Female

KW - Middle Aged

KW - Questionnaires

KW - Young Adult

KW - Socioeconomic Factors

KW - Regression Analysis

KW - Flow Cytometry

KW - Diagnostic and Statistical Manual of Mental Disorders

KW - T-Lymphocytes/metabolism

KW - Interferon-gamma/metabolism

KW - Tumor Necrosis Factor-alpha/metabolism

KW - Lymphocyte Count

KW - Hypothalamo-Hypophyseal System/physiopathology

KW - Cytokines/metabolism

KW - Depressive Disorder, Major/etiology/physiopathology

KW - Endocrine Glands/physiopathology

KW - Fatigue/etiology

KW - Hydrocortisone/blood

KW - Immune System/physiopathology

KW - Multiple Sclerosis, Relapsing-Remitting/complications/physiopathology/psychology

KW - Adult

KW - Humans

KW - Female

KW - Middle Aged

KW - Questionnaires

KW - Young Adult

KW - Socioeconomic Factors

KW - Regression Analysis

KW - Flow Cytometry

KW - Diagnostic and Statistical Manual of Mental Disorders

KW - T-Lymphocytes/metabolism

KW - Interferon-gamma/metabolism

KW - Tumor Necrosis Factor-alpha/metabolism

KW - Lymphocyte Count

KW - Hypothalamo-Hypophyseal System/physiopathology

KW - Cytokines/metabolism

KW - Depressive Disorder, Major/etiology/physiopathology

KW - Endocrine Glands/physiopathology

KW - Fatigue/etiology

KW - Hydrocortisone/blood

KW - Immune System/physiopathology

KW - Multiple Sclerosis, Relapsing-Remitting/complications/physiopathology/psychology

M3 - SCORING: Journal article

VL - 82

SP - 814

EP - 818

JO - J NEUROL NEUROSUR PS

JF - J NEUROL NEUROSUR PS

SN - 0022-3050

IS - 7

M1 - 7

ER -