Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors
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Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors. / Meyer, Thomas; Stanske, Beate; Kochen, Michael M; Cordes, Andreas; Yüksel, Iraz; Wachter, Rolf; Lüers, Claus; Scherer, Martin; Binder, Lutz; Pieske, Burkert; Herrmann-Lingen, Christoph.
In: PSYCHOSOMATICS, Vol. 51, No. 3, 21.05.2010, p. 248-56.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors
AU - Meyer, Thomas
AU - Stanske, Beate
AU - Kochen, Michael M
AU - Cordes, Andreas
AU - Yüksel, Iraz
AU - Wachter, Rolf
AU - Lüers, Claus
AU - Scherer, Martin
AU - Binder, Lutz
AU - Pieske, Burkert
AU - Herrmann-Lingen, Christoph
PY - 2010/5/21
Y1 - 2010/5/21
N2 - BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines.OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors.METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively.RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected].CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion.
AB - BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines.OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors.METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively.RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected].CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion.
KW - Aged
KW - Austria
KW - Cardiovascular Diseases
KW - Cohort Studies
KW - Coronary Disease
KW - Fatigue
KW - Female
KW - Heart Failure
KW - Humans
KW - Interleukin-10
KW - Interleukin-6
KW - Irritable Mood
KW - Male
KW - Middle Aged
KW - Morale
KW - Personality Inventory
KW - Primary Health Care
KW - Psychometrics
KW - Risk Factors
KW - Tumor Necrosis Factor-alpha
U2 - 10.1176/appi.psy.51.3.248
DO - 10.1176/appi.psy.51.3.248
M3 - SCORING: Journal article
C2 - 20484723
VL - 51
SP - 248
EP - 256
JO - PSYCHOSOMATICS
JF - PSYCHOSOMATICS
SN - 0033-3182
IS - 3
ER -