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Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors

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Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors. / Meyer, Thomas; Stanske, Beate; Kochen, Michael M; Cordes, Andreas; Yüksel, Iraz; Wachter, Rolf; Lüers, Claus; Scherer, Martin; Binder, Lutz; Pieske, Burkert; Herrmann-Lingen, Christoph.

in: PSYCHOSOMATICS, Jahrgang 51, Nr. 3, 21.05.2010, S. 248-56.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Meyer, T, Stanske, B, Kochen, MM, Cordes, A, Yüksel, I, Wachter, R, Lüers, C, Scherer, M, Binder, L, Pieske, B & Herrmann-Lingen, C 2010, 'Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors', PSYCHOSOMATICS, Jg. 51, Nr. 3, S. 248-56. https://doi.org/10.1176/appi.psy.51.3.248

APA

Meyer, T., Stanske, B., Kochen, M. M., Cordes, A., Yüksel, I., Wachter, R., Lüers, C., Scherer, M., Binder, L., Pieske, B., & Herrmann-Lingen, C. (2010). Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors. PSYCHOSOMATICS, 51(3), 248-56. https://doi.org/10.1176/appi.psy.51.3.248

Vancouver

Meyer T, Stanske B, Kochen MM, Cordes A, Yüksel I, Wachter R et al. Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors. PSYCHOSOMATICS. 2010 Mai 21;51(3):248-56. https://doi.org/10.1176/appi.psy.51.3.248

Bibtex

@article{1d7de627f91c429d896f257e2e0e0c08,
title = "Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors",
abstract = "BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines.OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors.METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively.RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected].CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion.",
keywords = "Aged, Austria, Cardiovascular Diseases, Cohort Studies, Coronary Disease, Fatigue, Female, Heart Failure, Humans, Interleukin-10, Interleukin-6, Irritable Mood, Male, Middle Aged, Morale, Personality Inventory, Primary Health Care, Psychometrics, Risk Factors, Tumor Necrosis Factor-alpha",
author = "Thomas Meyer and Beate Stanske and Kochen, {Michael M} and Andreas Cordes and Iraz Y{\"u}ksel and Rolf Wachter and Claus L{\"u}ers and Martin Scherer and Lutz Binder and Burkert Pieske and Christoph Herrmann-Lingen",
year = "2010",
month = may,
day = "21",
doi = "10.1176/appi.psy.51.3.248",
language = "English",
volume = "51",
pages = "248--56",
journal = "PSYCHOSOMATICS",
issn = "0033-3182",
publisher = "American Psychiatric Publishing Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Elevated serum levels of interleukin-10 and tumor necrosis factor α [corrected] are both associated with vital exhaustion in patients with cardiovascular risk factors

AU - Meyer, Thomas

AU - Stanske, Beate

AU - Kochen, Michael M

AU - Cordes, Andreas

AU - Yüksel, Iraz

AU - Wachter, Rolf

AU - Lüers, Claus

AU - Scherer, Martin

AU - Binder, Lutz

AU - Pieske, Burkert

AU - Herrmann-Lingen, Christoph

PY - 2010/5/21

Y1 - 2010/5/21

N2 - BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines.OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors.METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively.RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected].CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion.

AB - BACKGROUND: Vital exhaustion, a psychological state characterized by unusual fatigue, irritability, and feelings of demoralization, has been identified as a risk factor for cardiovascular diseases and linked to elevated levels of pro-inflammatory cytokines.OBJECTIVE: The purpose of this study was to investigate the relationship between vital exhaustion and cytokine levels in patients with cardiovascular risk factors.METHOD: The entire cohort consisted of 356 primary-care patients with cardiovascular risk factors who participated in a study of early recognition of heart failure. All participants completed the Maastricht questionnaire (MQ) for assessing vital exhaustion. Cytokine serum levels were measured in all those subjects (N=178) who were assigned to the highest and lowest quartiles of the MQ, respectively.RESULTS: We found that elevated serum concentrations of IL-6, TNFα, and IL-10, but not IL-1β or natriuretic peptides were associated with high MQ scores indicative of vital exhaustion. Using logistic regression analyses controlling for clinical variables and Type D personality, both TNFα (multivariate odds ratio [OR] =1.86; 95%-confidence interval [CI] =1.30-2.68; p=0.001) and IL-10(OR=1.62; 95%-CI=1.15-2.28; p=0.006), but not other cytokines significantly predicted vital exhaustion independently of other clinical and laboratory parameters examined [corrected].CONCLUSION: The subjective state of vital exhaustion is linked to a substantial alteration in the pattern of secreted cytokines. Data suggest that a disturbance in the levels of both pro-inflammatory and anti-inflammatory mediators, rather than isolated stimulation by pro-inflammatory cytokines, is associated with the mental and physical changes of vital exhaustion.

KW - Aged

KW - Austria

KW - Cardiovascular Diseases

KW - Cohort Studies

KW - Coronary Disease

KW - Fatigue

KW - Female

KW - Heart Failure

KW - Humans

KW - Interleukin-10

KW - Interleukin-6

KW - Irritable Mood

KW - Male

KW - Middle Aged

KW - Morale

KW - Personality Inventory

KW - Primary Health Care

KW - Psychometrics

KW - Risk Factors

KW - Tumor Necrosis Factor-alpha

U2 - 10.1176/appi.psy.51.3.248

DO - 10.1176/appi.psy.51.3.248

M3 - SCORING: Journal article

C2 - 20484723

VL - 51

SP - 248

EP - 256

JO - PSYCHOSOMATICS

JF - PSYCHOSOMATICS

SN - 0033-3182

IS - 3

ER -