Research ExplorerPublicationsElevated CD57 and CD95 expressions are associated with lower...

Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment

Standard

Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment. / Lu, I; Eberhard, Johanna; Ahmad, F; Bhatnagar, N; Behrens, G; Jacobs, R; Schmidt, R E; Meyer-Olson, D.

In: IMMUNOL LETT, Vol. 158, No. 1-2, 03.12.2013, p. 1-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lu, I, Eberhard, J, Ahmad, F, Bhatnagar, N, Behrens, G, Jacobs, R, Schmidt, RE & Meyer-Olson, D 2013, 'Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment', IMMUNOL LETT, vol. 158, no. 1-2, pp. 1-6. https://doi.org/10.1016/j.imlet.2013.11.014

APA

Lu, I., Eberhard, J., Ahmad, F., Bhatnagar, N., Behrens, G., Jacobs, R., Schmidt, R. E., & Meyer-Olson, D. (2013). Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment. IMMUNOL LETT, 158(1-2), 1-6. https://doi.org/10.1016/j.imlet.2013.11.014

Vancouver

Lu I, Eberhard J, Ahmad F, Bhatnagar N, Behrens G, Jacobs R et al. Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment. IMMUNOL LETT. 2013 Dec 3;158(1-2):1-6. https://doi.org/10.1016/j.imlet.2013.11.014

Bibtex

@article{b5f66050968c4d9dabbd334ea11399a1,
title = "Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment",
abstract = "The goal of this study was to understand how immune reconstitution through ART in HIV-1 infected patients affects CD4(+) recent thymic emigrants (identified as CD31(+) na{\"i}ve T cells). We performed FACS analysis of CD4(+) CD31(+) na{\"i}ve T cells from PBMCs in a cross-sectional age-matched cohort, including 25 healthy controls (HC), 18 untreated HIV-1 infected viremic progressors (VP), 10 untreated HIV-1 infected viral controllers (VC), and 24 HIV-1 infected immune responders (IR) following ART. Our data reveal that 37.5% of IR failed to restore their CD4(+) CD31(+) na{\"i}ve T cell counts. In addition, significantly higher expressions of Ki67, CD57, and CD95 were observed in CD4(+) CD31(+) na{\"i}ve T cells of both VP and IR comparing to HC and VC. The significantly elevated CD57 and CD95 expressions are observed in IR with low CD4(+) CD31(+) na{\"i}ve T cell counts. Therefore, our data indicate an incomplete immune reconstitution of CD4(+) CD31(+) na{\"i}ve T cells in more than one third of IR, which is associated with HIV-1 driven immunological phenotypic alterations. ",
keywords = "Adult, Aged, Anti-Retroviral Agents/therapeutic use, Biomarkers, Pharmacological/metabolism, CD4-Positive T-Lymphocytes/drug effects, CD57 Antigens/genetics, Cross-Sectional Studies, Disease Progression, Female, HIV Infections/drug therapy, HIV-1/immunology, Humans, Lymphocyte Count, Male, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1/metabolism, T-Lymphocyte Subsets/drug effects, Thymus Gland/immunology, Up-Regulation, fas Receptor/genetics",
author = "I Lu and Johanna Eberhard and F Ahmad and N Bhatnagar and G Behrens and R Jacobs and Schmidt, {R E} and D Meyer-Olson",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = dec,
day = "3",
doi = "10.1016/j.imlet.2013.11.014",
language = "English",
volume = "158",
pages = "1--6",
journal = "IMMUNOL LETT",
issn = "0165-2478",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment

AU - Lu, I

AU - Eberhard, Johanna

AU - Ahmad, F

AU - Bhatnagar, N

AU - Behrens, G

AU - Jacobs, R

AU - Schmidt, R E

AU - Meyer-Olson, D

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/12/3

Y1 - 2013/12/3

N2 - The goal of this study was to understand how immune reconstitution through ART in HIV-1 infected patients affects CD4(+) recent thymic emigrants (identified as CD31(+) naïve T cells). We performed FACS analysis of CD4(+) CD31(+) naïve T cells from PBMCs in a cross-sectional age-matched cohort, including 25 healthy controls (HC), 18 untreated HIV-1 infected viremic progressors (VP), 10 untreated HIV-1 infected viral controllers (VC), and 24 HIV-1 infected immune responders (IR) following ART. Our data reveal that 37.5% of IR failed to restore their CD4(+) CD31(+) naïve T cell counts. In addition, significantly higher expressions of Ki67, CD57, and CD95 were observed in CD4(+) CD31(+) naïve T cells of both VP and IR comparing to HC and VC. The significantly elevated CD57 and CD95 expressions are observed in IR with low CD4(+) CD31(+) naïve T cell counts. Therefore, our data indicate an incomplete immune reconstitution of CD4(+) CD31(+) naïve T cells in more than one third of IR, which is associated with HIV-1 driven immunological phenotypic alterations.

AB - The goal of this study was to understand how immune reconstitution through ART in HIV-1 infected patients affects CD4(+) recent thymic emigrants (identified as CD31(+) naïve T cells). We performed FACS analysis of CD4(+) CD31(+) naïve T cells from PBMCs in a cross-sectional age-matched cohort, including 25 healthy controls (HC), 18 untreated HIV-1 infected viremic progressors (VP), 10 untreated HIV-1 infected viral controllers (VC), and 24 HIV-1 infected immune responders (IR) following ART. Our data reveal that 37.5% of IR failed to restore their CD4(+) CD31(+) naïve T cell counts. In addition, significantly higher expressions of Ki67, CD57, and CD95 were observed in CD4(+) CD31(+) naïve T cells of both VP and IR comparing to HC and VC. The significantly elevated CD57 and CD95 expressions are observed in IR with low CD4(+) CD31(+) naïve T cell counts. Therefore, our data indicate an incomplete immune reconstitution of CD4(+) CD31(+) naïve T cells in more than one third of IR, which is associated with HIV-1 driven immunological phenotypic alterations.

KW - Adult

KW - Aged

KW - Anti-Retroviral Agents/therapeutic use

KW - Biomarkers, Pharmacological/metabolism

KW - CD4-Positive T-Lymphocytes/drug effects

KW - CD57 Antigens/genetics

KW - Cross-Sectional Studies

KW - Disease Progression

KW - Female

KW - HIV Infections/drug therapy

KW - HIV-1/immunology

KW - Humans

KW - Lymphocyte Count

KW - Male

KW - Middle Aged

KW - Platelet Endothelial Cell Adhesion Molecule-1/metabolism

KW - T-Lymphocyte Subsets/drug effects

KW - Thymus Gland/immunology

KW - Up-Regulation

KW - fas Receptor/genetics

U2 - 10.1016/j.imlet.2013.11.014

DO - 10.1016/j.imlet.2013.11.014

M3 - SCORING: Journal article

C2 - 24291117

VL - 158

SP - 1

EP - 6

JO - IMMUNOL LETT

JF - IMMUNOL LETT

SN - 0165-2478

IS - 1-2

ER -