Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment
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Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment. / Lu, I; Eberhard, Johanna; Ahmad, F; Bhatnagar, N; Behrens, G; Jacobs, R; Schmidt, R E; Meyer-Olson, D.
in: IMMUNOL LETT, Jahrgang 158, Nr. 1-2, 03.12.2013, S. 1-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Elevated CD57 and CD95 expressions are associated with lower numbers of CD4⁺ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment
AU - Lu, I
AU - Eberhard, Johanna
AU - Ahmad, F
AU - Bhatnagar, N
AU - Behrens, G
AU - Jacobs, R
AU - Schmidt, R E
AU - Meyer-Olson, D
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013/12/3
Y1 - 2013/12/3
N2 - The goal of this study was to understand how immune reconstitution through ART in HIV-1 infected patients affects CD4(+) recent thymic emigrants (identified as CD31(+) naïve T cells). We performed FACS analysis of CD4(+) CD31(+) naïve T cells from PBMCs in a cross-sectional age-matched cohort, including 25 healthy controls (HC), 18 untreated HIV-1 infected viremic progressors (VP), 10 untreated HIV-1 infected viral controllers (VC), and 24 HIV-1 infected immune responders (IR) following ART. Our data reveal that 37.5% of IR failed to restore their CD4(+) CD31(+) naïve T cell counts. In addition, significantly higher expressions of Ki67, CD57, and CD95 were observed in CD4(+) CD31(+) naïve T cells of both VP and IR comparing to HC and VC. The significantly elevated CD57 and CD95 expressions are observed in IR with low CD4(+) CD31(+) naïve T cell counts. Therefore, our data indicate an incomplete immune reconstitution of CD4(+) CD31(+) naïve T cells in more than one third of IR, which is associated with HIV-1 driven immunological phenotypic alterations.
AB - The goal of this study was to understand how immune reconstitution through ART in HIV-1 infected patients affects CD4(+) recent thymic emigrants (identified as CD31(+) naïve T cells). We performed FACS analysis of CD4(+) CD31(+) naïve T cells from PBMCs in a cross-sectional age-matched cohort, including 25 healthy controls (HC), 18 untreated HIV-1 infected viremic progressors (VP), 10 untreated HIV-1 infected viral controllers (VC), and 24 HIV-1 infected immune responders (IR) following ART. Our data reveal that 37.5% of IR failed to restore their CD4(+) CD31(+) naïve T cell counts. In addition, significantly higher expressions of Ki67, CD57, and CD95 were observed in CD4(+) CD31(+) naïve T cells of both VP and IR comparing to HC and VC. The significantly elevated CD57 and CD95 expressions are observed in IR with low CD4(+) CD31(+) naïve T cell counts. Therefore, our data indicate an incomplete immune reconstitution of CD4(+) CD31(+) naïve T cells in more than one third of IR, which is associated with HIV-1 driven immunological phenotypic alterations.
KW - Adult
KW - Aged
KW - Anti-Retroviral Agents/therapeutic use
KW - Biomarkers, Pharmacological/metabolism
KW - CD4-Positive T-Lymphocytes/drug effects
KW - CD57 Antigens/genetics
KW - Cross-Sectional Studies
KW - Disease Progression
KW - Female
KW - HIV Infections/drug therapy
KW - HIV-1/immunology
KW - Humans
KW - Lymphocyte Count
KW - Male
KW - Middle Aged
KW - Platelet Endothelial Cell Adhesion Molecule-1/metabolism
KW - T-Lymphocyte Subsets/drug effects
KW - Thymus Gland/immunology
KW - Up-Regulation
KW - fas Receptor/genetics
U2 - 10.1016/j.imlet.2013.11.014
DO - 10.1016/j.imlet.2013.11.014
M3 - SCORING: Journal article
C2 - 24291117
VL - 158
SP - 1
EP - 6
JO - IMMUNOL LETT
JF - IMMUNOL LETT
SN - 0165-2478
IS - 1-2
ER -