Efficacy of two different CHX-containing desensitizers
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Efficacy of two different CHX-containing desensitizers : a controlled double-blind study. / Drebenstedt, S; Zapf, Antonia ; Rödig, T; Mausberg, R F; Ziebolz, D.
In: OPER DENT, Vol. 37, No. 2, 15.12.2011, p. 161-171.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Efficacy of two different CHX-containing desensitizers
T2 - a controlled double-blind study
AU - Drebenstedt, S
AU - Zapf, Antonia
AU - Rödig, T
AU - Mausberg, R F
AU - Ziebolz, D
PY - 2011/12/15
Y1 - 2011/12/15
N2 - The aim of this study was to compare the effectiveness and duration of action of the tooth desensitization agent Cervitec (C) vs that of the new Cervitec Plus (C+). In this monocentric, single-center, three-armed, controlled, double-blind study, 120 subjects were randomly assigned to one of three groups:group I received Cervitec Plus (C+), group II received Cervitec (C), and group III received placebo (P). Varnishes were applied after base-line determination of cervical dentin hyper-sensitivity using a pain score of one or higher.Re-evaluation was performed 1, 7, 30, and 90 days after application. Statistical evaluation was carried out using nonparametric statistics for relative effects and analysis of variance(ANOVA). Thirty days after application of Cand C+, all hypersensitivity decreased significantly in relation to baseline measurements(p<0.001), with no changes taking place in the placebo group. Significant differences were observed between C and C+ vs placebo(p<0.001), whereas no significant difference between C and C+ was seen after 30 days(p=0.840). After 90 days, the reduction in hypersensitivity with C+ was still significant compared with baseline measurements(p=0.001). However, C was not significantly different compared with baseline measurements (p=0.05). Analysis of all hypersensitive posterior teeth examined showed no significant difference between C and C+ after 90 days(p=0.362). For anterior teeth, the difference between C and C+ was significant (p=0.012).Both C and C+ reduce cervical tooth hypersensitivity, whereas C+ reduces hypersensitivity for a longer period of time.
AB - The aim of this study was to compare the effectiveness and duration of action of the tooth desensitization agent Cervitec (C) vs that of the new Cervitec Plus (C+). In this monocentric, single-center, three-armed, controlled, double-blind study, 120 subjects were randomly assigned to one of three groups:group I received Cervitec Plus (C+), group II received Cervitec (C), and group III received placebo (P). Varnishes were applied after base-line determination of cervical dentin hyper-sensitivity using a pain score of one or higher.Re-evaluation was performed 1, 7, 30, and 90 days after application. Statistical evaluation was carried out using nonparametric statistics for relative effects and analysis of variance(ANOVA). Thirty days after application of Cand C+, all hypersensitivity decreased significantly in relation to baseline measurements(p<0.001), with no changes taking place in the placebo group. Significant differences were observed between C and C+ vs placebo(p<0.001), whereas no significant difference between C and C+ was seen after 30 days(p=0.840). After 90 days, the reduction in hypersensitivity with C+ was still significant compared with baseline measurements(p=0.001). However, C was not significantly different compared with baseline measurements (p=0.05). Analysis of all hypersensitive posterior teeth examined showed no significant difference between C and C+ after 90 days(p=0.362). For anterior teeth, the difference between C and C+ was significant (p=0.012).Both C and C+ reduce cervical tooth hypersensitivity, whereas C+ reduces hypersensitivity for a longer period of time.
KW - Adult
KW - Chlorhexidine
KW - Dentin
KW - Dentin Desensitizing Agents
KW - Dentin Sensitivity
KW - Double-Blind Method
KW - Drug Combinations
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Placebos
KW - Polyvinyls
KW - Thymol
KW - Tooth Cervix
KW - Treatment Outcome
KW - Comparative Study
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.2341/10-231-C
DO - 10.2341/10-231-C
M3 - SCORING: Journal article
C2 - 22166108
VL - 37
SP - 161
EP - 171
JO - OPER DENT
JF - OPER DENT
SN - 0361-7734
IS - 2
ER -