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Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease

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Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease. / Becker-Grünig, Tabea; Klose, Hans; Ehlken, Nicola; Lichtblau, Mona; Nagel, Christian; Fischer, Christine; Gorenflo, Matthias; Tiede, Henning; Schranz, Dietmar; Hager, Alfred; Kaemmerer, Harald; Miera, Oliver; Ulrich, Silvia; Speich, Rudolf; Uiker, Sören; Grünig, Ekkehard.

In: INT J CARDIOL, Vol. 168, No. 1, 20.09.2013, p. 375-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Becker-Grünig, T, Klose, H, Ehlken, N, Lichtblau, M, Nagel, C, Fischer, C, Gorenflo, M, Tiede, H, Schranz, D, Hager, A, Kaemmerer, H, Miera, O, Ulrich, S, Speich, R, Uiker, S & Grünig, E 2013, 'Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease', INT J CARDIOL, vol. 168, no. 1, pp. 375-81. https://doi.org/10.1016/j.ijcard.2012.09.036

APA

Becker-Grünig, T., Klose, H., Ehlken, N., Lichtblau, M., Nagel, C., Fischer, C., Gorenflo, M., Tiede, H., Schranz, D., Hager, A., Kaemmerer, H., Miera, O., Ulrich, S., Speich, R., Uiker, S., & Grünig, E. (2013). Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease. INT J CARDIOL, 168(1), 375-81. https://doi.org/10.1016/j.ijcard.2012.09.036

Vancouver

Becker-Grünig T, Klose H, Ehlken N, Lichtblau M, Nagel C, Fischer C et al. Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease. INT J CARDIOL. 2013 Sep 20;168(1):375-81. https://doi.org/10.1016/j.ijcard.2012.09.036

Bibtex

@article{137e83ab63ee4e7f8edca3b6252d9a33,
title = "Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease",
abstract = "BACKGROUND: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH).METHODS: Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months.RESULTS: Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years.CONCLUSION: Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.",
keywords = "Adult, Exercise, Exercise Therapy, Female, Follow-Up Studies, Heart Defects, Congenital, Hospitalization, Humans, Hypertension, Pulmonary, Male, Middle Aged, Oxygen Consumption, Prospective Studies, Treatment Outcome",
author = "Tabea Becker-Gr{\"u}nig and Hans Klose and Nicola Ehlken and Mona Lichtblau and Christian Nagel and Christine Fischer and Matthias Gorenflo and Henning Tiede and Dietmar Schranz and Alfred Hager and Harald Kaemmerer and Oliver Miera and Silvia Ulrich and Rudolf Speich and S{\"o}ren Uiker and Ekkehard Gr{\"u}nig",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = sep,
day = "20",
doi = "10.1016/j.ijcard.2012.09.036",
language = "English",
volume = "168",
pages = "375--81",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease

AU - Becker-Grünig, Tabea

AU - Klose, Hans

AU - Ehlken, Nicola

AU - Lichtblau, Mona

AU - Nagel, Christian

AU - Fischer, Christine

AU - Gorenflo, Matthias

AU - Tiede, Henning

AU - Schranz, Dietmar

AU - Hager, Alfred

AU - Kaemmerer, Harald

AU - Miera, Oliver

AU - Ulrich, Silvia

AU - Speich, Rudolf

AU - Uiker, Sören

AU - Grünig, Ekkehard

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/9/20

Y1 - 2013/9/20

N2 - BACKGROUND: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH).METHODS: Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months.RESULTS: Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years.CONCLUSION: Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.

AB - BACKGROUND: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH).METHODS: Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months.RESULTS: Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years.CONCLUSION: Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.

KW - Adult

KW - Exercise

KW - Exercise Therapy

KW - Female

KW - Follow-Up Studies

KW - Heart Defects, Congenital

KW - Hospitalization

KW - Humans

KW - Hypertension, Pulmonary

KW - Male

KW - Middle Aged

KW - Oxygen Consumption

KW - Prospective Studies

KW - Treatment Outcome

U2 - 10.1016/j.ijcard.2012.09.036

DO - 10.1016/j.ijcard.2012.09.036

M3 - SCORING: Journal article

C2 - 23041100

VL - 168

SP - 375

EP - 381

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 1

ER -