Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease
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Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease. / Becker-Grünig, Tabea; Klose, Hans; Ehlken, Nicola; Lichtblau, Mona; Nagel, Christian; Fischer, Christine; Gorenflo, Matthias; Tiede, Henning; Schranz, Dietmar; Hager, Alfred; Kaemmerer, Harald; Miera, Oliver; Ulrich, Silvia; Speich, Rudolf; Uiker, Sören; Grünig, Ekkehard.
in: INT J CARDIOL, Jahrgang 168, Nr. 1, 20.09.2013, S. 375-81.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease
AU - Becker-Grünig, Tabea
AU - Klose, Hans
AU - Ehlken, Nicola
AU - Lichtblau, Mona
AU - Nagel, Christian
AU - Fischer, Christine
AU - Gorenflo, Matthias
AU - Tiede, Henning
AU - Schranz, Dietmar
AU - Hager, Alfred
AU - Kaemmerer, Harald
AU - Miera, Oliver
AU - Ulrich, Silvia
AU - Speich, Rudolf
AU - Uiker, Sören
AU - Grünig, Ekkehard
N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PY - 2013/9/20
Y1 - 2013/9/20
N2 - BACKGROUND: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH).METHODS: Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months.RESULTS: Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years.CONCLUSION: Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.
AB - BACKGROUND: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH).METHODS: Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3 weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15 weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21 ± 14 months.RESULTS: Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60 ± 23 mm Hg) were included. Patients significantly improved the mean distance walked in 6 min compared to baseline by 63 ± 47 m after 3 weeks (p<0.001) and by 67 ± 59 m after 15 weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15 weeks. The 1- and 2-year survival rates were 100%, the transplantation-free survival rate was 100% after 1 year and 93% after 2 years.CONCLUSION: Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results.
KW - Adult
KW - Exercise
KW - Exercise Therapy
KW - Female
KW - Follow-Up Studies
KW - Heart Defects, Congenital
KW - Hospitalization
KW - Humans
KW - Hypertension, Pulmonary
KW - Male
KW - Middle Aged
KW - Oxygen Consumption
KW - Prospective Studies
KW - Treatment Outcome
U2 - 10.1016/j.ijcard.2012.09.036
DO - 10.1016/j.ijcard.2012.09.036
M3 - SCORING: Journal article
C2 - 23041100
VL - 168
SP - 375
EP - 381
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
IS - 1
ER -