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Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study.

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Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study. a phase II study. / Kittner, Thomas; Rudolf, Jens; Fages, Joan Falco; Legmann, Paul; Aschauer, Manuela; Repa, Imre; Alvares, Marta Rodriguez; Savalegui, Ibone; Ittrich, Harald; Geterud, Kjell; de Kevviler, Eric; Ayuso, Juan; Lockhart, Mark E; Blum, Alain; Iliasch, Herbert; Leisinger, Gerda; van Beek, E J R; Reid, Allan W; Brown, Jeffrey J; Yu, Thomas C; Flamm, Scott D; Düber, Christoph; Judmaier, Werner; Reimer, Peter; Stiskal, Michael; Kramann, Bernhard; Wolff, Steve; Blankenstein, Christiane.

In: EUR J RADIOL, Vol. 64, No. 3, 3, 01.12.2007, p. 456-464.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kittner, T, Rudolf, J, Fages, JF, Legmann, P, Aschauer, M, Repa, I, Alvares, MR, Savalegui, I, Ittrich, H, Geterud, K, de Kevviler, E, Ayuso, J, Lockhart, ME, Blum, A, Iliasch, H, Leisinger, G, van Beek, EJR, Reid, AW, Brown, JJ, Yu, TC, Flamm, SD, Düber, C, Judmaier, W, Reimer, P, Stiskal, M, Kramann, B, Wolff, S & Blankenstein, C 2007, 'Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study. a phase II study', EUR J RADIOL, vol. 64, no. 3, 3, pp. 456-464. https://doi.org/10.1016/j.ejrad.2007.02.034

APA

Kittner, T., Rudolf, J., Fages, J. F., Legmann, P., Aschauer, M., Repa, I., Alvares, M. R., Savalegui, I., Ittrich, H., Geterud, K., de Kevviler, E., Ayuso, J., Lockhart, M. E., Blum, A., Iliasch, H., Leisinger, G., van Beek, E. J. R., Reid, A. W., Brown, J. J., ... Blankenstein, C. (2007). Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study. a phase II study. EUR J RADIOL, 64(3), 456-464. [3]. https://doi.org/10.1016/j.ejrad.2007.02.034

Vancouver

Kittner T, Rudolf J, Fages JF, Legmann P, Aschauer M, Repa I et al. Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study. a phase II study. EUR J RADIOL. 2007 Dec 1;64(3):456-464. 3. https://doi.org/10.1016/j.ejrad.2007.02.034

Bibtex

@article{e10fe3857d094329bd13a585144f42be,
title = "Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study.: a phase II study",
abstract = "PURPOSE: To determine the most efficacious dose of gadodiamide for three-dimensional (3D) contrast-enhanced (CE) magnetic resonance angiography (MRA) of the renal arteries on a patient level based on the sensitivity in detecting the main hemodynamically relevant (> or =50% or occlusion) renal artery stenosis (RAS) using intra-arterial digital subtraction angiography (IA DSA) as the gold standard. MATERIALS AND METHODS: This prospective, randomized, double-blind, parallel-group, multicenter study included 273 patients referred to IA DSA for suspected RAS. Patients underwent 3D CE MRA after injection of 0.01, 0.05, 0.1, or 0.2mmol/kg of body weight gadodiamide (0.5mmol/ml). The images were assessed for location and degree of RAS by independent blinded readers (MRA: three readers, IA DSA: one reader). Hypothesis testing for a significant trend in sensitivity across dose groups was based on the one-sided Cochran-Armitage style trend test for each independent MRA reader. RESULTS: The lowest dose group (0.01mmol/kg) proved non-efficacious in detecting hemodynamically relevant (i.e., > or =50% or occlusion) RAS. A statistically significant dose trend (p",
keywords = "Adult, Aged, Aged, 80 and over, Angiography, Digital Subtraction, Contrast Media, Dose-Response Relationship, Drug, Double-Blind Method, Female, Gadolinium DTPA, Humans, Image Enhancement, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Injections, Intravenous, Magnetic Resonance Angiography, Male, Middle Aged, Prospective Studies, Renal Artery Obstruction, Safety, Sensitivity and Specificity, Treatment Outcome",
author = "Thomas Kittner and Jens Rudolf and Fages, {Joan Falco} and Paul Legmann and Manuela Aschauer and Imre Repa and Alvares, {Marta Rodriguez} and Ibone Savalegui and Harald Ittrich and Kjell Geterud and {de Kevviler}, Eric and Juan Ayuso and Lockhart, {Mark E} and Alain Blum and Herbert Iliasch and Gerda Leisinger and {van Beek}, {E J R} and Reid, {Allan W} and Brown, {Jeffrey J} and Yu, {Thomas C} and Flamm, {Scott D} and Christoph D{\"u}ber and Werner Judmaier and Peter Reimer and Michael Stiskal and Bernhard Kramann and Steve Wolff and Christiane Blankenstein",
year = "2007",
month = dec,
day = "1",
doi = "10.1016/j.ejrad.2007.02.034",
language = "English",
volume = "64",
pages = "456--464",
journal = "EUR J RADIOL",
issn = "0720-048X",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Efficacy and safety of gadodiamide (Gd-DTPA-BMA) in renal 3D-magnetic resonance angiography (MRA): a phase II study.

T2 - a phase II study

AU - Kittner, Thomas

AU - Rudolf, Jens

AU - Fages, Joan Falco

AU - Legmann, Paul

AU - Aschauer, Manuela

AU - Repa, Imre

AU - Alvares, Marta Rodriguez

AU - Savalegui, Ibone

AU - Ittrich, Harald

AU - Geterud, Kjell

AU - de Kevviler, Eric

AU - Ayuso, Juan

AU - Lockhart, Mark E

AU - Blum, Alain

AU - Iliasch, Herbert

AU - Leisinger, Gerda

AU - van Beek, E J R

AU - Reid, Allan W

AU - Brown, Jeffrey J

AU - Yu, Thomas C

AU - Flamm, Scott D

AU - Düber, Christoph

AU - Judmaier, Werner

AU - Reimer, Peter

AU - Stiskal, Michael

AU - Kramann, Bernhard

AU - Wolff, Steve

AU - Blankenstein, Christiane

PY - 2007/12/1

Y1 - 2007/12/1

N2 - PURPOSE: To determine the most efficacious dose of gadodiamide for three-dimensional (3D) contrast-enhanced (CE) magnetic resonance angiography (MRA) of the renal arteries on a patient level based on the sensitivity in detecting the main hemodynamically relevant (> or =50% or occlusion) renal artery stenosis (RAS) using intra-arterial digital subtraction angiography (IA DSA) as the gold standard. MATERIALS AND METHODS: This prospective, randomized, double-blind, parallel-group, multicenter study included 273 patients referred to IA DSA for suspected RAS. Patients underwent 3D CE MRA after injection of 0.01, 0.05, 0.1, or 0.2mmol/kg of body weight gadodiamide (0.5mmol/ml). The images were assessed for location and degree of RAS by independent blinded readers (MRA: three readers, IA DSA: one reader). Hypothesis testing for a significant trend in sensitivity across dose groups was based on the one-sided Cochran-Armitage style trend test for each independent MRA reader. RESULTS: The lowest dose group (0.01mmol/kg) proved non-efficacious in detecting hemodynamically relevant (i.e., > or =50% or occlusion) RAS. A statistically significant dose trend (p

AB - PURPOSE: To determine the most efficacious dose of gadodiamide for three-dimensional (3D) contrast-enhanced (CE) magnetic resonance angiography (MRA) of the renal arteries on a patient level based on the sensitivity in detecting the main hemodynamically relevant (> or =50% or occlusion) renal artery stenosis (RAS) using intra-arterial digital subtraction angiography (IA DSA) as the gold standard. MATERIALS AND METHODS: This prospective, randomized, double-blind, parallel-group, multicenter study included 273 patients referred to IA DSA for suspected RAS. Patients underwent 3D CE MRA after injection of 0.01, 0.05, 0.1, or 0.2mmol/kg of body weight gadodiamide (0.5mmol/ml). The images were assessed for location and degree of RAS by independent blinded readers (MRA: three readers, IA DSA: one reader). Hypothesis testing for a significant trend in sensitivity across dose groups was based on the one-sided Cochran-Armitage style trend test for each independent MRA reader. RESULTS: The lowest dose group (0.01mmol/kg) proved non-efficacious in detecting hemodynamically relevant (i.e., > or =50% or occlusion) RAS. A statistically significant dose trend (p

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Angiography, Digital Subtraction

KW - Contrast Media

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Female

KW - Gadolinium DTPA

KW - Humans

KW - Image Enhancement

KW - Image Processing, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Injections, Intravenous

KW - Magnetic Resonance Angiography

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Renal Artery Obstruction

KW - Safety

KW - Sensitivity and Specificity

KW - Treatment Outcome

U2 - 10.1016/j.ejrad.2007.02.034

DO - 10.1016/j.ejrad.2007.02.034

M3 - SCORING: Journal article

C2 - 17412546

VL - 64

SP - 456

EP - 464

JO - EUR J RADIOL

JF - EUR J RADIOL

SN - 0720-048X

IS - 3

M1 - 3

ER -