Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial
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Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial. / Zülke, Andrea E.; Pabst, Alexander; Luppa, Melanie; Oey, Anke; Weise, Solveig; Fankhänel, Thomas; Kosilek, Robert P.; Schillok, Hannah; Brettschneider, Christian; Czock, David; Wiese, Birgitt; Thyrian, Jochen René; Hoffmann, Wolfgang; Frese, Thomas; Gensichen, Jochen; König, Hans-Helmut; Kaduszkiewicz, Hanna; Riedel-Heller, Steffi G.
In: ALZHEIMERS DEMENT, Vol. 20, No. 8, 01.08.2024, p. 5684-5694.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial
AU - Zülke, Andrea E.
AU - Pabst, Alexander
AU - Luppa, Melanie
AU - Oey, Anke
AU - Weise, Solveig
AU - Fankhänel, Thomas
AU - Kosilek, Robert P.
AU - Schillok, Hannah
AU - Brettschneider, Christian
AU - Czock, David
AU - Wiese, Birgitt
AU - Thyrian, Jochen René
AU - Hoffmann, Wolfgang
AU - Frese, Thomas
AU - Gensichen, Jochen
AU - König, Hans-Helmut
AU - Kaduszkiewicz, Hanna
AU - Riedel-Heller, Steffi G.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - INTRODUCTION: Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODS: Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTS: The intervention reduced LIBRA scores, indicating decreased dementia risk at follow-up (b = -0.63, 95% confidence interval [CI]: -1.14, -0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSION: The AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.HIGHLIGHTS: The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at-risk population.
AB - INTRODUCTION: Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODS: Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTS: The intervention reduced LIBRA scores, indicating decreased dementia risk at follow-up (b = -0.63, 95% confidence interval [CI]: -1.14, -0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSION: The AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.HIGHLIGHTS: The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at-risk population.
KW - dementia
KW - lifestyle
KW - prevention
KW - randomized controlled trial
KW - risk factor
U2 - 10.1002/alz.14097
DO - 10.1002/alz.14097
M3 - SCORING: Journal article
C2 - 38967275
VL - 20
SP - 5684
EP - 5694
JO - ALZHEIMERS DEMENT
JF - ALZHEIMERS DEMENT
SN - 1552-5260
IS - 8
ER -