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Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial

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Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial. / Zülke, Andrea E.; Pabst, Alexander; Luppa, Melanie; Oey, Anke; Weise, Solveig; Fankhänel, Thomas; Kosilek, Robert P.; Schillok, Hannah; Brettschneider, Christian; Czock, David; Wiese, Birgitt; Thyrian, Jochen René; Hoffmann, Wolfgang; Frese, Thomas; Gensichen, Jochen; König, Hans-Helmut; Kaduszkiewicz, Hanna; Riedel-Heller, Steffi G.

in: ALZHEIMERS DEMENT, Jahrgang 20, Nr. 8, 01.08.2024, S. 5684-5694.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zülke, AE, Pabst, A, Luppa, M, Oey, A, Weise, S, Fankhänel, T, Kosilek, RP, Schillok, H, Brettschneider, C, Czock, D, Wiese, B, Thyrian, JR, Hoffmann, W, Frese, T, Gensichen, J, König, H-H, Kaduszkiewicz, H & Riedel-Heller, SG 2024, 'Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial', ALZHEIMERS DEMENT, Jg. 20, Nr. 8, S. 5684-5694. https://doi.org/10.1002/alz.14097

APA

Zülke, A. E., Pabst, A., Luppa, M., Oey, A., Weise, S., Fankhänel, T., Kosilek, R. P., Schillok, H., Brettschneider, C., Czock, D., Wiese, B., Thyrian, J. R., Hoffmann, W., Frese, T., Gensichen, J., König, H-H., Kaduszkiewicz, H., & Riedel-Heller, S. G. (2024). Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial. ALZHEIMERS DEMENT, 20(8), 5684-5694. https://doi.org/10.1002/alz.14097

Vancouver

Zülke AE, Pabst A, Luppa M, Oey A, Weise S, Fankhänel T et al. Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial. ALZHEIMERS DEMENT. 2024 Aug 1;20(8):5684-5694. https://doi.org/10.1002/alz.14097

Bibtex

@article{a796b182e8ab4412a34db7bd7ce16791,
title = "Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial",
abstract = "INTRODUCTION: Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODS: Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTS: The intervention reduced LIBRA scores, indicating decreased dementia risk at follow-up (b = -0.63, 95% confidence interval [CI]: -1.14, -0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSION: The AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.HIGHLIGHTS: The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at-risk population.",
keywords = "dementia, lifestyle, prevention, randomized controlled trial, risk factor",
author = "Z{\"u}lke, {Andrea E.} and Alexander Pabst and Melanie Luppa and Anke Oey and Solveig Weise and Thomas Fankh{\"a}nel and Kosilek, {Robert P.} and Hannah Schillok and Christian Brettschneider and David Czock and Birgitt Wiese and Thyrian, {Jochen Ren{\'e}} and Wolfgang Hoffmann and Thomas Frese and Jochen Gensichen and Hans-Helmut K{\"o}nig and Hanna Kaduszkiewicz and Riedel-Heller, {Steffi G.}",
year = "2024",
month = aug,
day = "1",
doi = "10.1002/alz.14097",
language = "English",
volume = "20",
pages = "5684--5694",
journal = "ALZHEIMERS DEMENT",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Effects of a multidomain intervention against cognitive decline on dementia risk profiles — Results from the AgeWell.de trial

AU - Zülke, Andrea E.

AU - Pabst, Alexander

AU - Luppa, Melanie

AU - Oey, Anke

AU - Weise, Solveig

AU - Fankhänel, Thomas

AU - Kosilek, Robert P.

AU - Schillok, Hannah

AU - Brettschneider, Christian

AU - Czock, David

AU - Wiese, Birgitt

AU - Thyrian, Jochen René

AU - Hoffmann, Wolfgang

AU - Frese, Thomas

AU - Gensichen, Jochen

AU - König, Hans-Helmut

AU - Kaduszkiewicz, Hanna

AU - Riedel-Heller, Steffi G.

PY - 2024/8/1

Y1 - 2024/8/1

N2 - INTRODUCTION: Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODS: Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTS: The intervention reduced LIBRA scores, indicating decreased dementia risk at follow-up (b = -0.63, 95% confidence interval [CI]: -1.14, -0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSION: The AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.HIGHLIGHTS: The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at-risk population.

AB - INTRODUCTION: Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.METHODS: Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.RESULTS: The intervention reduced LIBRA scores, indicating decreased dementia risk at follow-up (b = -0.63, 95% confidence interval [CI]: -1.14, -0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18).DISCUSSION: The AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions.HIGHLIGHTS: The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at-risk population.

KW - dementia

KW - lifestyle

KW - prevention

KW - randomized controlled trial

KW - risk factor

U2 - 10.1002/alz.14097

DO - 10.1002/alz.14097

M3 - SCORING: Journal article

C2 - 38967275

VL - 20

SP - 5684

EP - 5694

JO - ALZHEIMERS DEMENT

JF - ALZHEIMERS DEMENT

SN - 1552-5260

IS - 8

ER -