Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature
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Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature. / Sutter, Jan Peter; Chindo, Ben A.; Becker, Axel.
In: BEHAV BRAIN RES, Vol. 2019, No. 367, 23.07.2019, p. 215-220.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature
AU - Sutter, Jan Peter
AU - Chindo, Ben A.
AU - Becker, Axel
PY - 2019/7/23
Y1 - 2019/7/23
N2 - Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. The extract did not interfere with the acquisition and consolidation of the conditioned avoidance reaction (CAR), but did diminish the retrieval of CAR. The extract dose-dependently reduced body core temperature; this was significantly ameliorated by the use of amphetamine. The results confirmed the neuroleptic-like efficacy of FP, probably via the modulation of dopaminergic neurons.
AB - Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. The extract did not interfere with the acquisition and consolidation of the conditioned avoidance reaction (CAR), but did diminish the retrieval of CAR. The extract dose-dependently reduced body core temperature; this was significantly ameliorated by the use of amphetamine. The results confirmed the neuroleptic-like efficacy of FP, probably via the modulation of dopaminergic neurons.
M3 - SCORING: Journal article
C2 - 30965062
VL - 2019
SP - 215
EP - 220
JO - BEHAV BRAIN RES
JF - BEHAV BRAIN RES
SN - 0166-4328
IS - 367
ER -