Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature

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Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature. / Sutter, Jan Peter; Chindo, Ben A.; Becker, Axel.

in: BEHAV BRAIN RES, Jahrgang 2019, Nr. 367, 23.07.2019, S. 215-220.

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@article{5ee84482596e4811b658330c14aabcf3,
title = "Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature",
abstract = "Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. The extract did not interfere with the acquisition and consolidation of the conditioned avoidance reaction (CAR), but did diminish the retrieval of CAR. The extract dose-dependently reduced body core temperature; this was significantly ameliorated by the use of amphetamine. The results confirmed the neuroleptic-like efficacy of FP, probably via the modulation of dopaminergic neurons.",
author = "Sutter, {Jan Peter} and Chindo, {Ben A.} and Axel Becker",
year = "2019",
month = jul,
day = "23",
language = "English",
volume = "2019",
pages = "215--220",
journal = "BEHAV BRAIN RES",
issn = "0166-4328",
publisher = "Elsevier",
number = "367",

}

RIS

TY - JOUR

T1 - Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature

AU - Sutter, Jan Peter

AU - Chindo, Ben A.

AU - Becker, Axel

PY - 2019/7/23

Y1 - 2019/7/23

N2 - Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. The extract did not interfere with the acquisition and consolidation of the conditioned avoidance reaction (CAR), but did diminish the retrieval of CAR. The extract dose-dependently reduced body core temperature; this was significantly ameliorated by the use of amphetamine. The results confirmed the neuroleptic-like efficacy of FP, probably via the modulation of dopaminergic neurons.

AB - Preparations of Ficus platyphylla are used in Nigeria's folk medicine to manage a variety of diseases, including insomnia, psychoses, depression, epilepsy, pain, and inflammation. In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. The extract did not interfere with the acquisition and consolidation of the conditioned avoidance reaction (CAR), but did diminish the retrieval of CAR. The extract dose-dependently reduced body core temperature; this was significantly ameliorated by the use of amphetamine. The results confirmed the neuroleptic-like efficacy of FP, probably via the modulation of dopaminergic neurons.

M3 - SCORING: Journal article

C2 - 30965062

VL - 2019

SP - 215

EP - 220

JO - BEHAV BRAIN RES

JF - BEHAV BRAIN RES

SN - 0166-4328

IS - 367

ER -