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Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study

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Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study. / Auer, Matthias K; Sack, Markus; Lenz, Jenny N; Jakovcevski, Mira; Biedermann, Sarah V; Falfán-Melgoza, Claudia; Deussing, Jan; Steinle, Jörg; Bielohuby, Maximilian; Bidlingmaier, Martin; Pfister, Frederik; Stalla, Günter K; Ende, Gabriele; Weber-Fahr, Wolfgang; Fuss, Johannes; Gass, Peter.

In: J CEREBR BLOOD F MET, Vol. 35, No. 4, 04.2015, p. 554-64.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Auer, MK, Sack, M, Lenz, JN, Jakovcevski, M, Biedermann, SV, Falfán-Melgoza, C, Deussing, J, Steinle, J, Bielohuby, M, Bidlingmaier, M, Pfister, F, Stalla, GK, Ende, G, Weber-Fahr, W, Fuss, J & Gass, P 2015, 'Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study', J CEREBR BLOOD F MET, vol. 35, no. 4, pp. 554-64. https://doi.org/10.1038/jcbfm.2014.231

APA

Auer, M. K., Sack, M., Lenz, J. N., Jakovcevski, M., Biedermann, S. V., Falfán-Melgoza, C., Deussing, J., Steinle, J., Bielohuby, M., Bidlingmaier, M., Pfister, F., Stalla, G. K., Ende, G., Weber-Fahr, W., Fuss, J., & Gass, P. (2015). Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study. J CEREBR BLOOD F MET, 35(4), 554-64. https://doi.org/10.1038/jcbfm.2014.231

Vancouver

Auer MK, Sack M, Lenz JN, Jakovcevski M, Biedermann SV, Falfán-Melgoza C et al. Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study. J CEREBR BLOOD F MET. 2015 Apr;35(4):554-64. https://doi.org/10.1038/jcbfm.2014.231

Bibtex

@article{b1c571fe726541e3a8d0f6c1d83ed128,
title = "Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study",
abstract = "Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy ((1)HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation.",
keywords = "Animals, Aspartic Acid, Brain, Carbohydrate Metabolism, Diet, Dipeptides, Energy Intake, Fatty Acids, Glucose, Glutamic Acid, Hyperglycemia, Insulin, Magnetic Resonance Spectroscopy, Male, Mice, Mice, Inbred C57BL, Obesity, Physical Conditioning, Animal, Protons, Running, Journal Article, Research Support, Non-U.S. Gov't",
author = "Auer, {Matthias K} and Markus Sack and Lenz, {Jenny N} and Mira Jakovcevski and Biedermann, {Sarah V} and Claudia Falf{\'a}n-Melgoza and Jan Deussing and J{\"o}rg Steinle and Maximilian Bielohuby and Martin Bidlingmaier and Frederik Pfister and Stalla, {G{\"u}nter K} and Gabriele Ende and Wolfgang Weber-Fahr and Johannes Fuss and Peter Gass",
year = "2015",
month = apr,
doi = "10.1038/jcbfm.2014.231",
language = "English",
volume = "35",
pages = "554--64",
journal = "J CEREBR BLOOD F MET",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of a high-caloric diet and physical exercise on brain metabolite levels a combined proton MRS and histologic study

AU - Auer, Matthias K

AU - Sack, Markus

AU - Lenz, Jenny N

AU - Jakovcevski, Mira

AU - Biedermann, Sarah V

AU - Falfán-Melgoza, Claudia

AU - Deussing, Jan

AU - Steinle, Jörg

AU - Bielohuby, Maximilian

AU - Bidlingmaier, Martin

AU - Pfister, Frederik

AU - Stalla, Günter K

AU - Ende, Gabriele

AU - Weber-Fahr, Wolfgang

AU - Fuss, Johannes

AU - Gass, Peter

PY - 2015/4

Y1 - 2015/4

N2 - Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy ((1)HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation.

AB - Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS). It has been suggested that one mechanism in this context is the promotion of neuroinflammation. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we conducted a study investigating the effects of physical exercise in a cafeteria-diet mouse model on CNS metabolites by means of in vivo proton magnetic resonance spectroscopy ((1)HMRS). In addition postmortem histologic and real-time (RT)-PCR analyses for inflammatory markers were performed. Cafeteria diet induced obesity and hyperglycemia, which was only partially moderated by exercise. It also induced several changes in CNS metabolites such as reduced hippocampal glutamate (Glu), choline-containing compounds (tCho) and N-acetylaspartate (NAA)+N-acetyl-aspartyl-glutamic acid (NAAG) (tNAA) levels, whereas opposite effects were seen for running. No association of these effects with markers of central inflammation could be observed. These findings suggest that while voluntary wheel running alone is insufficient to prevent the unfavorable peripheral sequelae of the diet, it counteracted many changes in brain metabolites. The observed effects seem to be independent of neuroinflammation.

KW - Animals

KW - Aspartic Acid

KW - Brain

KW - Carbohydrate Metabolism

KW - Diet

KW - Dipeptides

KW - Energy Intake

KW - Fatty Acids

KW - Glucose

KW - Glutamic Acid

KW - Hyperglycemia

KW - Insulin

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Obesity

KW - Physical Conditioning, Animal

KW - Protons

KW - Running

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/jcbfm.2014.231

DO - 10.1038/jcbfm.2014.231

M3 - SCORING: Journal article

C2 - 25564238

VL - 35

SP - 554

EP - 564

JO - J CEREBR BLOOD F MET

JF - J CEREBR BLOOD F MET

SN - 0271-678X

IS - 4

ER -